STATISTICAL SIGNIFICANCE IN OMIC DATA ANALYSES - Alternative/Complementary Method for Efficient Automatic Identification of Statistically Significant Tests in High Throughput Biological Studies

Christine Nardini, Luca Benini, Michael D. Kuo

2008

Abstract

The post-Genomic Era is characterized by the proliferation of high-throughput platforms that allow the parallel study of a complete body of molecules in one single run of experiments (omic approach). Analysis and integration of omic data represent one of the most challenging frontiers for all the disciplines related to Systems Biology. From the computational perspective this requires, among others, the massive use of automated approaches in several steps of the complex analysis pipeline, often consisting of cascades of statistical tests. In this frame, the identification of statistical significance has been one of the early challenges in the handling of omic data and remains a critical step due to the multiple hypotheses testing issue, given the large number of hypotheses examined at one time. Two main approaches are currently used: p-values based on random permutation approaches and the False Discovery Rate. Both give meaningful and important results, however they suffer respectively from being computationally heavy -due to the large number of data that has to be generated-, or extremely flexible with respect to the definition of the significance threshold, leading to difficulties in standardization. We present here a complementary/alternative approach to these current ones and discuss performances and limitations.

Paper Citation

in Harvard Style

Nardini C., Benini L. and D. Kuo M. (2008). STATISTICAL SIGNIFICANCE IN OMIC DATA ANALYSES - Alternative/Complementary Method for Efficient Automatic Identification of Statistically Significant Tests in High Throughput Biological Studies . In Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2008) ISBN 978-989-8111-18-0, pages 56-63. DOI: 10.5220/0001059900560063

in Bibtex Style

@conference{biosignals08,
author={Christine Nardini and Luca Benini and Michael D. Kuo},
title={STATISTICAL SIGNIFICANCE IN OMIC DATA ANALYSES - Alternative/Complementary Method for Efficient Automatic Identification of Statistically Significant Tests in High Throughput Biological Studies},
booktitle={Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2008)},
year={2008},
pages={56-63},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001059900560063},
isbn={978-989-8111-18-0},
}

in EndNote Style

TY - CONF
JO - Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2008)
TI - STATISTICAL SIGNIFICANCE IN OMIC DATA ANALYSES - Alternative/Complementary Method for Efficient Automatic Identification of Statistically Significant Tests in High Throughput Biological Studies
SN - 978-989-8111-18-0
AU - Nardini C.
AU - Benini L.
AU - D. Kuo M.
PY - 2008
SP - 56
EP - 63
DO - 10.5220/0001059900560063