A Robust Temperature Controller Design for an Innovative Hyperthermic Intraperitoneal Chemotherapy Equipment

Iulia Clitan, Corneliu Lungoci, Vlad Muresan, Daniel Moga, Valentin Sita

2015

Abstract

This paper presents an advanced control structure for controlling the heating process of cytostatic solution used in regional chemotherapy. The solution temperature control is an individual control structure which is desired to be implemented on hyperthermic intraperitioneal chemotherapy (HIPEC) innovative device. Cytoreductive surgery followed by HIPEC represents a therapeutic solution for patients suffering from peritoneal carcinomatosis, an abdominal cancer. An H∞ robust control structure is designed since the heating process model’s parameters depend on the solution’s delivery flow. It is considered that the heating process gain can vary from a nominal value to a maximum value, which represents an increase by up to 100% from the nominal value. The responses to a step input signal for the nominal case, and the cases when the gain varies by 50% or 100%, are simulated. The control structure is compared against a PID feasible controller by means of overall performances. It resulted that the robust controller generates the best performance set for the nominal gain and also for the case when the heating process gain varies.

References

  1. Clitan, I., Muresan, V., Moga, D., Sita, V., Lungoci, C., July 2015. Measured signal identification and temperature controller design for a HIPEC device. 38th International Conference on Telecommunications and Signal Processing TSP, Prague, Chech Repuplic, in press.
  2. Damen, A., Weinland, S., 2002. Robust control. Eindhoven University of Technology. Eindhoven, Chapter 7.
  3. Doyle, J., Glover, K., Khargonekar, P., Francis, B., 1989. State-space solutions to standard H-2 and H-infinity control problems, IEEE Trans. Auto. Control 34 (8), pp. 831-847.
  4. Gleben, O., Gilly, F. N., Arvieus, C., Cotte, E., Boutitie, F., Mansvelt, B., Bereder, J. M., Lorimier, G., Quenet, F., Elias, D., 2010. Peritoneal carcinomatosis from gastric cancer: A multi-institutional study of 159 patients treated by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy, Annals of Surgical Oncology 17, pp. 2370-2377.
  5. Gu, D. W., Petrov, P. H., Konstantinov, M. M., 2005. Robust control design with Matlab, Springer-verlag. London, Chapters 4 and 8.
  6. Inoan, I. , Abrudean, M. , Szelitzky, T., 2011. Robust H8 position control of an unloading machine from a rotary hearth furnace, Scientific bulletin of the Petru Maior University of Târgu Mure?, 8 (2), Petru Maior University Publisher, Targu Mures, pp. 38-43.
  7. Koppe, M. J., Boerman, O. C., Oyen, W. J. G., Bleichrodt, R. P., 2006. Peritoneal carcinomatosis of colorectal origin - Incidence and current treatment strategies, Annals of Surgery 242 (2), pp. 212-222.
  8. Levine, E. A., Blazer, D. G., Kim, M. K., Shen, P., Stewart, J. H., Guy, C., Hsu, D. S., 2012. Gene expression profiling of peritoneal metastases from appendiceal and colon cancer demonstrates unique biologic signatures and predicts patient outcomes, Journal of the American College of Surgeons, 214 (4), pp. 599 - 606.
  9. Lungoci, C., Raus, I., Oniu, T., Moga, D., Stroia, N., Muntean, V., Petreus, D., Mironiuc, I. A., 2014. Assessment of temperature distribution in intraperitoneal chemohyperthermia, International Conference on Advancements of Medicine and Health Care through Technology, IFMBE Proceeding, 44, pp. 193-196, Cluj-Napoca.
  10. Mikleš, D. J., Fikar, M., 2007. Process modelling, identification, and control, Springer. Verlag Berlin Heidelberg, Chapter 6 and 7.
  11. Ogata, K., 2009. Modern control engineering, Prentice Hall. New Jersey, 5th edition.
  12. Spratt, J. S., Adcock, R. A., Muskovin, M., Sherrill, W., Mckeown, J., 1980. Clinical delivery system for intraperitoneal hyperthermic chemotherapy, Cancer Research, 40 (2), pp. 256-260.
  13. Stroia, N., Moga, D., Lungoci, C., Moga, R., and Petreus, D., 2014. Development of a hyperthermic intraperitoneal chemotherapy equipment architecture based on the cyber-physical system paradigm, Third International Workshop on Cyber Physical Systems. Bucuresti.
  14. Sugarbaker, P. H., 2005. Technical handbook for the integration of cytoreductive surgery and perioperative intraperitoneal chemotherapy into the surgical management of gastrointestinal and gynecologic malignancy, The Ludann Company Grand Rapids, Michigan, 4th edition.
  15. Sugarbaker, P. H., Clarke, L., 2006. The approval process for hyperthermic intraoperative intraperitoneal chemotherapy, European Journal of Surgical Oncology, 32 (6), pp. 637-643.
  16. Sugarbaker, P. H., 2012, Cytoreductive surgery plus hyperthermic perioperative chemotherapy for selected patients with peritoneal metastases from colorectal cancer: a new standard of care or an experimental approach?, Gastroenterology Research and Practice, 2012 ID:309417, 9 pages.
  17. Szelitzky, T., Inoan, I., Dumitrache, D. C., 2011. Advantages of robust control for series load frequency controlled induction heating inverters, Journal of Control Engineering and Applied Informatics, 13 (1), pp. 62-68.
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Paper Citation


in Harvard Style

Clitan I., Lungoci C., Muresan V., Moga D. and Sita V. (2015). A Robust Temperature Controller Design for an Innovative Hyperthermic Intraperitoneal Chemotherapy Equipment . In Proceedings of the 12th International Conference on Informatics in Control, Automation and Robotics - Volume 2: ICINCO, ISBN 978-989-758-123-6, pages 84-91. DOI: 10.5220/0005543800840091


in Bibtex Style

@conference{icinco15,
author={Iulia Clitan and Corneliu Lungoci and Vlad Muresan and Daniel Moga and Valentin Sita},
title={A Robust Temperature Controller Design for an Innovative Hyperthermic Intraperitoneal Chemotherapy Equipment},
booktitle={Proceedings of the 12th International Conference on Informatics in Control, Automation and Robotics - Volume 2: ICINCO,},
year={2015},
pages={84-91},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005543800840091},
isbn={978-989-758-123-6},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 12th International Conference on Informatics in Control, Automation and Robotics - Volume 2: ICINCO,
TI - A Robust Temperature Controller Design for an Innovative Hyperthermic Intraperitoneal Chemotherapy Equipment
SN - 978-989-758-123-6
AU - Clitan I.
AU - Lungoci C.
AU - Muresan V.
AU - Moga D.
AU - Sita V.
PY - 2015
SP - 84
EP - 91
DO - 10.5220/0005543800840091