A CMOS Tracking System Approach for Cell Motility Assays

Cristina Martínez-Gómez, Cristina Martínez-Gómez, Alberto Olmo, Alberto Olmo, Gloria Huertas, Gloria Huertas, Pablo Pérez, Pablo Pérez, Andres Maldonado-Jacobi, Andres Maldonado-Jacobi, Alberto Yúfera, Alberto Yúfera

2017

Abstract

This work proposes a method for studying and monitoring in real-time a single cell on a 2D electrode matrix, of great interest in cell motility assays and in the characterization of cancer cell metastasis. A CMOS system proposal for cell location based on occupation maps data generated from Electrical Cell-substrate Impedance Spectroscopy (ECIS) has been developed. From this cell model, obtained from experimental assays data, an algorithm based on analysis of the 8 nearest neighbors has been implemented, allowing the evaluation of the cell center of mass. The path followed by a cell, proposing a Brownian route, has been simulated with the proposed algorithm. The presented results show the success of the approach, with accuracy over 95% in the determination of any coordinate (x, y) from the expected center of mass.

Paper Citation

in Harvard Style

Martínez-Gómez C., Olmo A., Huertas G., Pérez P., Maldonado-Jacobi A. and Yúfera A. (2017). A CMOS Tracking System Approach for Cell Motility Assays. In - BIODEVICES, (BIOSTEC 2017) ISBN , pages 0-0. DOI: 10.5220/0006291500001488

in Bibtex Style

@conference{biodevices17,
author={Cristina Martínez-Gómez and Alberto Olmo and Gloria Huertas and Pablo Pérez and Andres Maldonado-Jacobi and Alberto Yúfera},
title={A CMOS Tracking System Approach for Cell Motility Assays},
booktitle={ - BIODEVICES, (BIOSTEC 2017)},
year={2017},
pages={},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006291500001488},
isbn={},
}

in EndNote Style

TY - CONF

JO - - BIODEVICES, (BIOSTEC 2017)
TI - A CMOS Tracking System Approach for Cell Motility Assays
SN -
AU - Martínez-Gómez C.
AU - Olmo A.
AU - Huertas G.
AU - Pérez P.
AU - Maldonado-Jacobi A.
AU - Yúfera A.
PY - 2017
SP - 0
EP - 0
DO - 10.5220/0006291500001488