Testing Gb3(CD77) Expression Level in Cancer Cells

Shuhao Chen

2021

Abstract

Purpose: Pancreatic cancer and colon cancer are common cancer types that are lethal. This study tries to find the expression pattern of CD77 in cancer cells and investigate whether STxB-SN38 can be used for targeting therapy in Pancreatic cancer and colon cancer. STxB was proved to have high specificity of binding to CD77, and STxB is very efficient at cell killing. Methods: The experiments will use know human cell lines, ATCC and DSMZ. Flow cytometry is used for monitoring cell proliferation and counting. AnnexinV/PI will be used for killing measuring. Possible Results: There are 27 possible results Conclusion: The result of our study will contribute to future clinical trials of Stxs-SN38 targeted therapy. Future studies should focus on eliminating wrong pathways that Stxs-SN38 could kill normal cells. Detecting cancer at an early stage is still an important study to research more.

Paper Citation

in Harvard Style

Chen S. (2021). Testing Gb3(CD77) Expression Level in Cancer Cells. In Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH, ISBN 978-989-758-594-4, pages 203-208. DOI: 10.5220/0011242500003444

in Bibtex Style

@conference{caih21,
author={Shuhao Chen},
title={Testing Gb3(CD77) Expression Level in Cancer Cells},
booktitle={Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH,},
year={2021},
pages={203-208},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011242500003444},
isbn={978-989-758-594-4},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd Conference on Artificial Intelligence and Healthcare - Volume 1: CAIH,
TI - Testing Gb3(CD77) Expression Level in Cancer Cells
SN - 978-989-758-594-4
AU - Chen S.
PY - 2021
SP - 203
EP - 208
DO - 10.5220/0011242500003444