AVALANCHE PHOTODIODES FOR HIGH-RESOLUTION PET IMAGING SYSTEMS

R. Bugalho, B. Carriço, C. S. Ferreira, M. Ferreira, R. Moura, C. Ortigão, J. Pinheiro, P. Rodrigues, J. C. Silva, A. Trindade, J. Varela

2009

Abstract

A high-resolution Positron Emission Tomography (PET) scanner prototype, named Clear-PEM, was developed by the Portuguese PET Consortium in the framework of the Crystal Clear Collaboration (CCC). This scanner is a PET prototype dedicated for breast cancer imaging mammography, based on a novel readout scheme constituted by fine-pitch scintillator crystals, avalanche photodiodes (APD), low-noise high-gain frontend amplifiers and a reconfigurable FPGA-based electronics readout system. The Clear-PEM scanner is designed to exam both the breast and the auxiliary lymph node areas, aiming at the detection of tumours down to 2 mm in diameter. The prototype has two planar detector heads, each composed of 96 detector modules. Each detector module is composed of a matrix of 32 identical 2x2x20 mm3 LYSO:Ce scintillator crystals, read at both ends by Hamamatsu S8550 APD arrays (4x8) for Depth-of-Interaction (DOI) capability. The APD arrays were characterized through the measurement of gain and dark current as a function of bias voltage, under controlled conditions. A set of 984 APD arrays followed a well defined quality control (QC) protocol, aiming at the rejection of arrays not complying with the defined specifications. From the total of 984, only 1 (0.1%) was rejected, reassuring the trust in these detectors for prototype assembly and future applications.

References

  1. Abreu, M. C., Amaral, P., Carriço, B., Ferreira, M., Moura, R., Ortigãoo, C., Rato, P., and Varela, J. (2007). Characterization and quality control of avalanche PhotoDiode arrays for the Clear-PEM detector modules. Nucl. Instr. and Method., 576(1):19-22.
  2. Amaral, P., Carriço, B., Ferreira, M., Moura, R., Ortigão, C., Rodrigues, P., Silva, J. C., Trindade, A., and Varela, J. (2006). Performance and quality control of Clear-PEM detector modules. Nucl. Instr. and Method. in press.
  3. Albuquerque, E., Bento, P., Leong, C., Gonçalves, F., Nobre, J., Rego, J., Relvas, P., Lousã, P., Rodrigues, P., Teixeira, I. C., Teixeira, J. P., Silva, L., Silva, M. M., Trindade, A., and Varela, J. (2006). The ClearPEM electronics system. IEEE Trans. Nuc. Sci., 53(5):2704-2711.
  4. Crespo, P., Kapusta, M., Pawelke, J., Moszynski, M., and Enghardt, W. (2004). First in-beam PET imaging with LSO/APD array detectors. IEEE Trans. Nuc. Sci., 51(5):2654-2661.
  5. Kapusta, M., Crespo, P., Wolski, D., Moszynski, M., and Enghardt, W. (2003). Hamamatsu S8550 arrays for high-resolution scintillator matrices readout. Nucl. Instr. and Method., A504:139-142.
  6. P. Lecoq and J. Varela, Clear-PEM, a dedicated PET camera for mammography. Nucl. Instrum. Meth. vol A 486, pp.1-6, 2002.
  7. Melcher, C. L. and Schweitzer, J. S. (1992). Ceriumdoped lutetium oxyorthosilicate: a fast, efficient new scintillator. IEEE Trans. Nuc. Sci., 39(4):502-505.
  8. Moses, W. W. (2004). Positron emission mammography imaging. Nucl. Instr. and Method., A525(1-2).
  9. Mosset, J. B. (2006). Developpement d'un module de detection phoswich LSO%LuYAP pour le prototype de camera a positrons ClearPET. PhD thesis, Faculte des Sciences de base de lEcole Polytechnique Federale de Lausanne.
  10. Rodrigues, P.,. (2007). Study and Development of the Clear-PEM Trigger and Data Acquisition System ClearPET. PhD thesis, Instituto Superior Técnico, Universidade Técnica de Lisboa.
  11. Spanoudaki, V., McElroy, D. P., Zell, K., and Ziegler, S. I. (2005). Effect of temperature on the stability and performance of an LSO-APD PET scanner. In 2005 IEEE Nuclear Science Symposium Conference Record, pages 2785-2789.
  12. Shao, Y., Silverman, R. W., Farrell, R., Cirignamo, L., Grazioso, R., Shah, K. S., Visser, G., Clajus, M., Tumer, T. O., and Cherry, S. R. (2000). Design studies of a high resolution PET detector using APD arrays. IEEE Trans. Nuc. Sci., 47(3):1051-1057.
  13. Thompson, C. J. , Murthy, K., Picard, Y. , Weinberg, I. N. , Mako F. M. (1995) Positron Emission Mammography (PEM): a promising technique to detect breast cancer. IEEE Trans. Nucl. Sci. 42 1012- 1017.
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Paper Citation


in Harvard Style

Bugalho R., Carriço B., S. Ferreira C., Ferreira M., Moura R., Ortigão C., Pinheiro J., Rodrigues P., C. Silva J., Trindade A. and Varela J. (2009). AVALANCHE PHOTODIODES FOR HIGH-RESOLUTION PET IMAGING SYSTEMS . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2009) ISBN 978-989-8111- 64-7, pages 31-38. DOI: 10.5220/0001432900310038


in Bibtex Style

@conference{biodevices09,
author={R. Bugalho and B. Carriço and C. S. Ferreira and M. Ferreira and R. Moura and C. Ortigão and J. Pinheiro and P. Rodrigues and J. C. Silva and A. Trindade and J. Varela},
title={AVALANCHE PHOTODIODES FOR HIGH-RESOLUTION PET IMAGING SYSTEMS},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2009)},
year={2009},
pages={31-38},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001432900310038},
isbn={978-989-8111- 64-7},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2009)
TI - AVALANCHE PHOTODIODES FOR HIGH-RESOLUTION PET IMAGING SYSTEMS
SN - 978-989-8111- 64-7
AU - Bugalho R.
AU - Carriço B.
AU - S. Ferreira C.
AU - Ferreira M.
AU - Moura R.
AU - Ortigão C.
AU - Pinheiro J.
AU - Rodrigues P.
AU - C. Silva J.
AU - Trindade A.
AU - Varela J.
PY - 2009
SP - 31
EP - 38
DO - 10.5220/0001432900310038