Automatic Design Optimisation of Pharmaceutical Tablets using PDEs

Norhayati Ahmat, Gabriela González Castro, Hassan Ugail

2012

Abstract

Pharmaceutical tablets and capsules are the dominant forms for drug delivery. Both types of dosage forms need to be strong enough to handle different types of stress due to packaging and loading conditions before use. Hence, it is important to produce these pharmaceutical forms with maximum mechanical strength while conserving the properties of their active ingredients during the design process. The present work describes a methodology for parametric design and optimisation of a solid cylindrical tablet and a soft spherical capsule, which is based on the use of Partial Differential Equations (PDEs). The PDE-based formulation is capable of parameterising complex shapes using the information at some boundary curves that describe the shape. It is shown that the optimal designs of both tablet and capsule can be obtained using an automatic design optimisation which is performed by combining the PDE method and a standard method for numerical optimisation.

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Paper Citation


in Harvard Style

Ahmat N., González Castro G. and Ugail H. (2012). Automatic Design Optimisation of Pharmaceutical Tablets using PDEs . In Proceedings of the 2nd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: SIMULTECH, ISBN 978-989-8565-20-4, pages 125-130. DOI: 10.5220/0004059601250130


in Bibtex Style

@conference{simultech12,
author={Norhayati Ahmat and Gabriela González Castro and Hassan Ugail},
title={Automatic Design Optimisation of Pharmaceutical Tablets using PDEs},
booktitle={Proceedings of the 2nd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: SIMULTECH,},
year={2012},
pages={125-130},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004059601250130},
isbn={978-989-8565-20-4},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 2nd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: SIMULTECH,
TI - Automatic Design Optimisation of Pharmaceutical Tablets using PDEs
SN - 978-989-8565-20-4
AU - Ahmat N.
AU - González Castro G.
AU - Ugail H.
PY - 2012
SP - 125
EP - 130
DO - 10.5220/0004059601250130