Analysis of Impedance Spectroscopy Measurements of Biological Tissue using the Distribution of Relaxation Times Method

Roberto Giovanni Ramírez-Chavarría, Celia Sánchez-Pérez, Daniel Matatagui

2017

Abstract

This work proposes a method for analysing electrical impedance spectroscopy (EIS) measurements of biological tissue in the range of 100 Hz to 1 MHz by means of the distribution of relaxation times (DRT) to evaluate and study the different relaxation time constant involved in electrical response. We numerically analyse different configurations of RC circuits and compare the electrical response in time domain by DRT with that of classical EIS representation in frequency domain as Bode plots. Experimental validation of the technique using RC circuits, gives an error of less than 1% for the EIS measurement system with respect to theoretical calculation. We present preliminary measurements for WISTAR rat tissue samples of spleen, lung and kidney fixed in formaldehyde solution at 3.8% founding a more detailed occurrence of relaxation mechanism that could provide useful information about the structure and composition of biological tissues in a more precise way.

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Paper Citation


in Harvard Style

Ramírez-Chavarría R., Sánchez-Pérez C. and Matatagui D. (2017). Analysis of Impedance Spectroscopy Measurements of Biological Tissue using the Distribution of Relaxation Times Method . In Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2017) ISBN 978-989-758-216-5, pages 224-228. DOI: 10.5220/0006253902240228


in Bibtex Style

@conference{biodevices17,
author={Roberto Giovanni Ramírez-Chavarría and Celia Sánchez-Pérez and Daniel Matatagui},
title={Analysis of Impedance Spectroscopy Measurements of Biological Tissue using the Distribution of Relaxation Times Method},
booktitle={Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2017)},
year={2017},
pages={224-228},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006253902240228},
isbn={978-989-758-216-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2017)
TI - Analysis of Impedance Spectroscopy Measurements of Biological Tissue using the Distribution of Relaxation Times Method
SN - 978-989-758-216-5
AU - Ramírez-Chavarría R.
AU - Sánchez-Pérez C.
AU - Matatagui D.
PY - 2017
SP - 224
EP - 228
DO - 10.5220/0006253902240228