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Moscow Regional Research & Clinical Institute "MONIKI" named after M.F. Vladimirskiy and National Research Nuclear University MEPhI
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3 Papers

Optical Technology for Ultraviolet Erythema Assessment and Minimal Erythema Dose Determination in Healthy Volunteers

Topics: Biomechanical Devices; Biomedical Equipment & Instrumentation

Authors: Mikhail Makmatov-Rys 1 , Alexey Glazkov 1 , Irina Raznitsyna 1 , Dmitriy Kulikov 1 ; 2 , Anton Molochkov 1 , Albina Khlebnikova 1 , Ekaterina Kaznacheeva 3 , Alexey Sekirin 1 and Dmitry Rogatkin 1

Affiliations: 1 Moscow Regional Research and Clinical Institute "MONIKI", 61/2, Shchepkina Str., Moscow, RF, 129110, Russian Federation , 2 Institute of Public Health named after N.A. Semashko, 12/1c1 Vorontsovo Pole Str., Moscow, RF, 105064, Russian Federation , 3 Cosmetological Clinic «Lemark», Voronezh, 32 Vladimir Nevsky Str., RF, 394088, Russian Federation

Digital Object Identifier: 10.5220/0009177000730078

Proceedings of BIODEVICES 2020/BIOSTEC, ISBN: 978-989-758-398-8

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Currently, in clinical practice, the assessment of ultraviolet (UV) -induced erythema and the determination of the minimal erythema dose (MED) is done visually, which is subjective, inaccurate and associated with high variability of the results. To solve this problem, the application of optical methods seems promising, allowing us to evaluate changes in epidermis and dermis induced by UV exposure. In this study the analysis of endogenous fluorescence and microcirculation characteristics by non-invasive optical methods revealed the relationship between the intensity of endogenous fluorescence of porphyrins and oxygen consumption with a dose of UV radiation. The correlation of the intensity of endogenous fluorescence of the irradiated region normalized to intact tissue with a dose of UV was demonstrated. Therefore, optical diagnostic methods can be a promising tool for non-invasive and quantitative assessment of UV erythema and MED.

Optical Technology for Fibrotic Skin Changes Objectification in Experimental Systemic Scleroderma

Topics: Spectroscopic Applications; Diagnostic devices

Authors: Yulia Chursinova 1 , Dmitriy Kulikov 1 , Dmitry Rogatkin 1 , Irina Raznitsyna 2 ; 1 , Darya Mosalskaya 1 and Maksim Bobrov 1

Affiliations: 1 Moscow Regional Research and Clinical Institute "MONIKI", Russian Federation , 2 National Research Nuclear University MEPhI, Russian Federation

Digital Object Identifier: 10.5220/0006633101940199

Proceedings of BIODEVICES 2018/BIOSTEC, ISBN: 978-989-758-277-6

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Currently the examination of skin fibrosis is based on subjective non quantitative methods and requires invasive procedures. Optical techniques abled to evaluate different quantitative parameters of ordered tissues can be used to solve these problem. Measurements of endogenous fluorescence intensity, regional tissue oxyhemoglobin saturation, and blood filling volume allowed to define the high endogenous fluorescence intensity of porphyrin in skin fibrosis. Besides that, the decrease in oxygen intake parameters together with the fluorescence intensity increase of collagen was determined. Consequently the optical diagnostic techniques can become an effective method for skin fibrosis evaluation.

In Vivo Experimental Detection of Inflammatory Process in Tissues by Fluorescence Spectroscopy

Topic: Spectroscopic Applications

Authors: Irina Guseva 1 , Dmitriy Rogatkin 2 , Polina Kulikova 2 and Dmitriy Kulikov 2

Affiliations: 1 Moscow Regional Research & Clinical Institute "MONIKI" named after M.F. Vladimirskiy and National Research Nuclear University MEPhI, Russian Federation , 2 Moscow Regional Research & Clinical Institute "MONIKI" named after M.F. Vladimirskiy, Russian Federation

Digital Object Identifier: 10.5220/0005659301390144

Proceedings of BIODEVICES 2016/BIOSTEC, ISBN: 978-989-758-170-0

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Laser fluorescence spectroscopy (LFS) is widely used in medicine. Today, oncology and oncosurgery are considered as the most promising fields of its application. It is known that cancerous tissues are able to accumulate different porphyrins, both endogenous and exogenous, in enhanced amount due to increased metabolism in cancerous cells. So, LFS can be used in vivo for detection of malignant tumours as well as for real-time intraoperative imaging or diagnostics at a photodynamic therapy. One of the reason of the enhanced accumulation of porphyrins in tissues is a chronic hypoxia. Therefore, it was hypothesized, that LFS could also be used for diagnosis of local inflammation in tissues. Recently, some indirect data confirming the hypothesis was obtained when observed inflammation due to invasion of external substances into tissues. This study proves the hypothesis in a direct experiment with animals and laboratory tests. Enhanced fluorescence intensity of the exogenous photosensitizer was found in inflamed tissues. The direct association between intensity of the fluorescence, histological characteristics and blood test results was shown. It was found that the registered fluorescence signal correlates with neutrophil counts in blood of tested animals. It proves that LFS could be an effective tool for registration of local inflammation.
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Biomedical Engineering

Biomedical Instruments and Devices

Spectroscopic Applications

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