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Deparment of Dermatology and Venereology Faculty of Medicine Universitas Indonesia/ Dr. Cipto Mangunkusumo National General Hospital

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1 Papers

Drug Induced Hypersensitivity Syndrome (DIHS) Patient Characteristics in Dermatology and Venereology Department, Dr. Cipto Mangunkusumo National General Hospital in the Period 2014 to 2017

Authors: Teffy Nuary , Sarah Mahri and Windy Keumala B.

Affiliation: Deparment of Dermatology and Venereology Faculty of Medicine Universitas Indonesia/ Dr. Cipto Mangunkusumo National General Hospital, Indonesia

Digital Object Identifier: 10.5220/0008152301270131

Proceedings of RCD 2018, ISBN: 978-989-758-494-7

Quick Abstract

Drug induced hypersensitivity syndrome (DIHS) is a distinct, severe, idiosyncratic reaction to a drug characterized by a prolonged latency period with cutaneous presentation and internal organ involvement. In Asia, DIHS was reported to almost one tenth of adverse drug reaction cases, with a mortality rate ranged 3- 10%. The aim of this study are to describe the sociodemographic and clinical characteristics of patients with DIHS and causative agents in Dermatology and Venereology Department Dr. Cipto Mangunkusumo National General Hospital, Jakarta. This study is a descriptive study. Using medical records and electronic health record of patients with DIHS were retrospectively reviewed. During 2014-2017 we identified 18 female, 14 male patients, with age range 14-87 years. Onset of the disease since exposed by culprit drugs were 14-40 days.The most common underlying disease was accute infection disease (43,7%). The DIHS clinical features and laboratory finding in this study are fever (93,7%), maculopapular rash (90,6%), target lesions (12,5 %), facial oedema (21,5%), periorbital oedema (12,5%). lymph nodes enlargement (93,7%), eosinofilia (31,2 %) , elevating of liver function (100%), and one patients (3,1%) showed kidney involvement .The most common causative drugs were antibacterials (60 %). all patients, the causative drug was discontinued and treated with systemic corticosteroids. As the conclusion DIHS is a severe drug hypersensitivity reaction with prominent cutaneous and systemic manifestations. Dispite the limitations, this study present some variations of DIHS clinical features and many other drugs that implicated.