AN ONTOLOGICAL APPROACH TO REPRESENTING AND REASONING WITH TEMPORAL CONSTRAINTS IN CLINICAL TRIAL PROTOCOLS

Ravi D. Shankar, Susana B. Martins, Martin J. O’Connor, Amar K. Das

Abstract

Temporal constraints play an important role in the specification and implementation of clinical trial protocols, and subsequently, in the querying of the generated trial data. Protocols specify a temporal schedule of clinical trial activities such as tests, procedures, and medications. The schedule includes temporal constraints on the sequence of these activities, on their duration, and on potential cycles. In this paper, we present our approach to formally represent temporal constraints found in clinical trials. We have identified a representative set of temporal constraints found in protocols to study immune tolerance. Our research group has developed a temporal constraint ontology that allows us to formulate the temporal constraints to the extent required to support clinical trials management. We use this ontology to provide temporal annotation of clinical activities in an encoded clinical trial protocol. We have developed a temporal model that represents time-stamped data and facilitates interval-based temporal operations on the data. Using semantic web technologies, we are building a knowledge-based framework that integrates the temporal constraint ontology with the temporal model to support queries on clinical trial data. Using our approach, we can formally specify temporal constraints, and reason with the temporal knowledge to support management of clinical trials.

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Paper Citation


in Harvard Style

D. Shankar R., B. Martins S., J. O’Connor M. and K. Das A. (2008). AN ONTOLOGICAL APPROACH TO REPRESENTING AND REASONING WITH TEMPORAL CONSTRAINTS IN CLINICAL TRIAL PROTOCOLS . In Proceedings of the First International Conference on Health Informatics - Volume 1: HEALTHINF, (BIOSTEC 2008) ISBN 978-989-8111-16-6, pages 87-93. DOI: 10.5220/0001043800870093


in Bibtex Style

@conference{healthinf08,
author={Ravi D. Shankar and Susana B. Martins and Martin J. O’Connor and Amar K. Das},
title={AN ONTOLOGICAL APPROACH TO REPRESENTING AND REASONING WITH TEMPORAL CONSTRAINTS IN CLINICAL TRIAL PROTOCOLS},
booktitle={Proceedings of the First International Conference on Health Informatics - Volume 1: HEALTHINF, (BIOSTEC 2008)},
year={2008},
pages={87-93},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001043800870093},
isbn={978-989-8111-16-6},
}


in EndNote Style

TY - CONF
JO - Proceedings of the First International Conference on Health Informatics - Volume 1: HEALTHINF, (BIOSTEC 2008)
TI - AN ONTOLOGICAL APPROACH TO REPRESENTING AND REASONING WITH TEMPORAL CONSTRAINTS IN CLINICAL TRIAL PROTOCOLS
SN - 978-989-8111-16-6
AU - D. Shankar R.
AU - B. Martins S.
AU - J. O’Connor M.
AU - K. Das A.
PY - 2008
SP - 87
EP - 93
DO - 10.5220/0001043800870093