PROGRAMMABLE CYTOGENETIC SUBMICROLITRE LAB-ON-A-CHIP FOR MOLECULAR DIAGNOSTIC APPLICATIONS

Daniela Woide, Veronika Schlentner, Teresa Neumaier, Thorsten Wachtmeister, Herwig G. Paretzke, Zeno von Guttenberg, Achim Wixforth, Stefan Thalhammer

Abstract

This project focuses on the development of an acoustic driven, freely programmable multifunctional biochemical lab-on-a-chip. By combining different platform elements, like microdissection-, nanofluidic- and detection-modules, the lab-on-a-chip can be adapted to question- and patient-specific cytogenetic and forensic applications. In contrast to many common lab-on-a-chip approaches presently available, the fluidic handling is done on a planar surface of the lab-on-a-chip. Minute amounts of biochemical fluids are confined in ‘virtual’ reaction chambers and ‘virtual’ test tubes in the form of free droplets. The droplets, fluidic tracks and reaction sites are defined at the chip surface by a monolayer chemical modification of the chip surface. Surface acoustic waves are employed to agitate and actuate these little ‘virtual’ test tubes along predetermined trajectories. Well-defined investigations, controlled in the submicrolitre regime, can be conducted quickly and gently on the lab-on-a-chip.

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Paper Citation


in Harvard Style

Woide D., Schlentner V., Neumaier T., Wachtmeister T., G. Paretzke H., von Guttenberg Z., Wixforth A. and Thalhammer S. (2008). PROGRAMMABLE CYTOGENETIC SUBMICROLITRE LAB-ON-A-CHIP FOR MOLECULAR DIAGNOSTIC APPLICATIONS . In Proceedings of the First International Conference on Biomedical Electronics and Devices - Volume 2: BIODEVICES, (BIOSTEC 2008) ISBN 978-989-8111- 17-3, pages 256-261. DOI: 10.5220/0001048002560261


in Bibtex Style

@conference{biodevices08,
author={Daniela Woide and Veronika Schlentner and Teresa Neumaier and Thorsten Wachtmeister and Herwig G. Paretzke and Zeno von Guttenberg and Achim Wixforth and Stefan Thalhammer},
title={PROGRAMMABLE CYTOGENETIC SUBMICROLITRE LAB-ON-A-CHIP FOR MOLECULAR DIAGNOSTIC APPLICATIONS},
booktitle={Proceedings of the First International Conference on Biomedical Electronics and Devices - Volume 2: BIODEVICES, (BIOSTEC 2008)},
year={2008},
pages={256-261},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001048002560261},
isbn={978-989-8111- 17-3},
}


in EndNote Style

TY - CONF
JO - Proceedings of the First International Conference on Biomedical Electronics and Devices - Volume 2: BIODEVICES, (BIOSTEC 2008)
TI - PROGRAMMABLE CYTOGENETIC SUBMICROLITRE LAB-ON-A-CHIP FOR MOLECULAR DIAGNOSTIC APPLICATIONS
SN - 978-989-8111- 17-3
AU - Woide D.
AU - Schlentner V.
AU - Neumaier T.
AU - Wachtmeister T.
AU - G. Paretzke H.
AU - von Guttenberg Z.
AU - Wixforth A.
AU - Thalhammer S.
PY - 2008
SP - 256
EP - 261
DO - 10.5220/0001048002560261