ANIMAL STUDIES USING AN OXYGEN-TENSION SENSOR FOR TISSUE VIABILITY MONITORING

Dafina Tanase, Niels Komen, Arie Draaijer, Johan F. Lange, Gert-Jan Kleinrensink, Johannes Jeekel, Paddy J. French

Abstract

Leakage at the site of an anastomosis is the main, yet unsolved reason for mortality in abdominal surgery. Every year, a large number of patients die due to anastomotic leakage after surgery. An objective aid to monitor the anastomotic site pre- and postoperatively and detect leakage at an early stage, is needed. Therefore, a miniature, wireless measurement system to detect tissue viability during and after colon surgery (continuously for 7 days) is being developed. The complete sensor chip should include an oxygen-saturation sensor (sO2), an oxygen-tension sensor (pO2), a carbon-dioxide tension sensor (pCO2) and a temperature sensor. The present work focuses on the use of the oxygen-tension and temperature sensors for animal studies. Initial in-vivo measurements were carried out on the small and large intestines of male wistar rats. The main goal was to measure the distribution of pO2 on the colon around the anastomosis and to determine the changes in pO2 during repetitive ischemia-and-reperfusion experiments on the small intestine. The paper presents the obtained measurement results.

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Paper Citation


in Harvard Style

Tanase D., Komen N., Draaijer A., F. Lange J., Kleinrensink G., Jeekel J. and J. French P. (2008). ANIMAL STUDIES USING AN OXYGEN-TENSION SENSOR FOR TISSUE VIABILITY MONITORING . In Proceedings of the First International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2008) ISBN 978-989-8111- 17-3, pages 50-55. DOI: 10.5220/0001052300500055


in EndNote Style

TY - CONF
JO - Proceedings of the First International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2008)
TI - ANIMAL STUDIES USING AN OXYGEN-TENSION SENSOR FOR TISSUE VIABILITY MONITORING
SN - 978-989-8111- 17-3
AU - Tanase D.
AU - Komen N.
AU - Draaijer A.
AU - F. Lange J.
AU - Kleinrensink G.
AU - Jeekel J.
AU - J. French P.
PY - 2008
SP - 50
EP - 55
DO - 10.5220/0001052300500055


in Bibtex Style

@conference{biodevices08,
author={Dafina Tanase and Niels Komen and Arie Draaijer and Johan F. Lange and Gert-Jan Kleinrensink and Johannes Jeekel and Paddy J. French},
title={ANIMAL STUDIES USING AN OXYGEN-TENSION SENSOR FOR TISSUE VIABILITY MONITORING},
booktitle={Proceedings of the First International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2008)},
year={2008},
pages={50-55},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001052300500055},
isbn={978-989-8111- 17-3},
}