CARDIAC MAGNETIC FIELD MAP TOPOLOGY QUANTIFIED BY KULLBACK-LEIBLER ENTROPY IDENTIFIES PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY

A. Schirdewan, A. Gapelyuk, R. Fischer, L. Koch, H. Schütt, U. Zacharzowsky, R. Dietz, L. Thierfelder, N. Wessel

Abstract

Hypertrophic Cardiomyopathy (HCM) is defined clinically by the growing/thickening of especially the left heart muscle. In up to 70 % of cases, there is a family history of this condition. The individual risk for affected patients strongly varies and depends on the individual manifestation of the disease. Therefore, an early detection of the disease and identification of high-risk subforms is desirable. In this study we investigated the capability of cardiac magnetic field mapping (CMFM) to detect patients suffering from HCM (n=33, 43.8 ± 13 years, 13 women, 20 men; vs. a control group of healthy subjects, n=57, 39.6 ± 8.9 years; 22 women, 35 men; vs. patients with confirmed cardiac hypertrophy due to arterial hypertension, n=42, 49.7 ± 7.9 years, 15 women, 27 men). We introduce for the first time a combined diagnostic approach based on map topology quantification using Kullback-Leibler (KL) entropy and regional magnetic field strength parameters. The cardiac magnetic field was recorded over the anterior chest wall using a multichannel-LT-SQUID system. We show that our diagnostic approach allows not only detecting HCM affected individuals, but also discriminates different forms of the disease. Thus, CMFM including KL entropy based topology quantifications is a suitable tool for HCM screening.

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Paper Citation


in Harvard Style

Schirdewan A., Gapelyuk A., Fischer R., Koch L., Schütt H., Zacharzowsky U., Dietz R., Thierfelder L. and Wessel N. (2008). CARDIAC MAGNETIC FIELD MAP TOPOLOGY QUANTIFIED BY KULLBACK-LEIBLER ENTROPY IDENTIFIES PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY . In Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 2: BIOSIGNALS, (BIOSTEC 2008) ISBN 978-989-8111-18-0, pages 445-452. DOI: 10.5220/0001064504450452


in Bibtex Style

@conference{biosignals08,
author={A. Schirdewan and A. Gapelyuk and R. Fischer and L. Koch and H. Schütt and U. Zacharzowsky and R. Dietz and L. Thierfelder and N. Wessel},
title={CARDIAC MAGNETIC FIELD MAP TOPOLOGY QUANTIFIED BY KULLBACK-LEIBLER ENTROPY IDENTIFIES PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY},
booktitle={Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 2: BIOSIGNALS, (BIOSTEC 2008)},
year={2008},
pages={445-452},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001064504450452},
isbn={978-989-8111-18-0},
}


in EndNote Style

TY - CONF
JO - Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing - Volume 2: BIOSIGNALS, (BIOSTEC 2008)
TI - CARDIAC MAGNETIC FIELD MAP TOPOLOGY QUANTIFIED BY KULLBACK-LEIBLER ENTROPY IDENTIFIES PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
SN - 978-989-8111-18-0
AU - Schirdewan A.
AU - Gapelyuk A.
AU - Fischer R.
AU - Koch L.
AU - Schütt H.
AU - Zacharzowsky U.
AU - Dietz R.
AU - Thierfelder L.
AU - Wessel N.
PY - 2008
SP - 445
EP - 452
DO - 10.5220/0001064504450452