LABEL FREE BIO SENSING METHOD USING RADIO FREQUENCIES SPECTROSCOPY FOR CELL DETECTION AND DISCRIMINATION

Claire Dalmay, Arnaud Pothier, Pierre Blondy, Fabrice Lalloue, Marie-Odile Jauberteau

Abstract

This paper presents an original label free bio sensing method allowing the study of electrical properties of human cells and so potentially cell identification and discrimination. The proposed bio sensor is based on a planar resonator operating at microwave frequencies, fabricated using a standard microelectronic process. As the result its microscopic sensitive areas allow an improved detection at the cell scale which represents a significant step in the study of many biological phenomenon. Thanks to a specific experimental protocol, we present in this paper a simple method allowing electrical parameters measurement on a small number of cells with a good accuracy.

References

  1. Young-Il Kim, Yunkwon Park, Hong Koo Baik, 2007. “Development of LC resonator for label-free biomolecule detection”, Sensors and Actuators A.
  2. B. Blad, and B. Baldetorp, 1996. “Impedance spectra of tumour tissue in comparison with normal tissue; a possible clinical application for electrical impedance tomography”, Physiol.Meas., vol. 17, pp. 105- 115.
  3. T. W. Athey, M. A. Stuchly, S. S. Stuchly, 1982. “Measurement of radio frequency permittivity of biological tissues with an open-ended coaxial line : Part I,” IEEE Trans. Microwave Theory Tech,. vol. 82, pp. 82-86.
  4. N. Denef , L. Moreno-Hagelsieb, G. Laurent, R. Pampina, B. Foultier, J. Remacle, D. Flandre, 2004. “RF detection of DNA based on CMOS inductive and capacitive sensors”, EUMW Conference Digest, pp. 669-672.
  5. C. Dalmay, 2008. “Label free biosensors for human cell characterization using radio and microwave frequencies”, IEEE MTT-S International Microwave Symposium Digest, IMS 2008.
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Paper Citation


in Harvard Style

Dalmay C., Pothier A., Blondy P., Lalloue F. and Jauberteau M. (2009). LABEL FREE BIO SENSING METHOD USING RADIO FREQUENCIES SPECTROSCOPY FOR CELL DETECTION AND DISCRIMINATION . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2009) ISBN 978-989-8111- 64-7, pages 3-6. DOI: 10.5220/0001122800030006


in Bibtex Style

@conference{biodevices09,
author={Claire Dalmay and Arnaud Pothier and Pierre Blondy and Fabrice Lalloue and Marie-Odile Jauberteau},
title={LABEL FREE BIO SENSING METHOD USING RADIO FREQUENCIES SPECTROSCOPY FOR CELL DETECTION AND DISCRIMINATION},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2009)},
year={2009},
pages={3-6},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001122800030006},
isbn={978-989-8111- 64-7},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2009)
TI - LABEL FREE BIO SENSING METHOD USING RADIO FREQUENCIES SPECTROSCOPY FOR CELL DETECTION AND DISCRIMINATION
SN - 978-989-8111- 64-7
AU - Dalmay C.
AU - Pothier A.
AU - Blondy P.
AU - Lalloue F.
AU - Jauberteau M.
PY - 2009
SP - 3
EP - 6
DO - 10.5220/0001122800030006