PULMONARY PRESSURE-VOLUME CURVES OF ELASTASE-TREATED AND CONTROL RATS

Angelos Kyriazis, Jesús Ruiz-Cabello, Ignacio Rodríguez, Sandra Pérez-Rial, Laura del Puerto Nevado, Germán Peces-Barba

Abstract

The objective of this experiment is to test if the emphysematous and the control rats can be classified according to the pulmonary pressure-volume curves. Emphysema was simulated by instilling elastase to the rat lungs and leaving them to develop the disease for 6 weeks. The pressure-volume curves were acquired by a customdesigned ventilator. The pressure at the inflection point of the inhalation limb of the curves has been used as a feature to separate the two classes of animals. The extension of emphysema in the rat lungs was assessed post-mortem by measuring the mean surface of the alveoli. This was possible after extracting the lungs, slicing them, photographing them and analysing the pictures. The mean surface of the alveoli distinguishes clearly the control from the emphysematous rats, which verifies the deteriorating effect of elastase over the lung alveoli. However, no clear correlation was found between the pressure-volume curves inflection-points and the animal classes.

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Paper Citation


in Harvard Style

Kyriazis A., Ruiz-Cabello J., Rodríguez I., Pérez-Rial S., del Puerto Nevado L. and Peces-Barba G. (2009). PULMONARY PRESSURE-VOLUME CURVES OF ELASTASE-TREATED AND CONTROL RATS . In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2009) ISBN 978-989-8111-65-4, pages 480-486. DOI: 10.5220/0001537604800486


in Bibtex Style

@conference{biosignals09,
author={Angelos Kyriazis and Jesús Ruiz-Cabello and Ignacio Rodríguez and Sandra Pérez-Rial and Laura del Puerto Nevado and Germán Peces-Barba},
title={PULMONARY PRESSURE-VOLUME CURVES OF ELASTASE-TREATED AND CONTROL RATS},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2009)},
year={2009},
pages={480-486},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001537604800486},
isbn={978-989-8111-65-4},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2009)
TI - PULMONARY PRESSURE-VOLUME CURVES OF ELASTASE-TREATED AND CONTROL RATS
SN - 978-989-8111-65-4
AU - Kyriazis A.
AU - Ruiz-Cabello J.
AU - Rodríguez I.
AU - Pérez-Rial S.
AU - del Puerto Nevado L.
AU - Peces-Barba G.
PY - 2009
SP - 480
EP - 486
DO - 10.5220/0001537604800486