THE POWER SPECTRA RESPONSE OF STROKE VOLUME AND ARTERIAL BLOOD PRESSURE VARIABILITY SIGNALS TO AUTONOMIC NERVOUS SYSTEM MODULATION OF THE HEART

Abdul-Hakeem H. AlOmari, Andis Graudins, Andrey V. Savkin

Abstract

This study presents results that describe the short term oscillations in SBPV and SVV signals due to calcium channel blockers poisoning with verapamil treated with continuous infusion of levosimendan. In addition, we used average spectra of these oscillations to observe the activity and sympathovagal balance of the autonomic nervous system. Then, we compared the average spectra obtained from both signals. The frequency contents of the average spectra of SVV and SBPV signals to levosimendan treatment of verapamil-poisoned rats were analyzed and related to the activity of sympathetic and parasympathetic tones. In control group, average spectra of SVV and SBPV exhibited a low-frequency band (LF: 0.03−0.8 Hz) peaked at ~ 0.4 Hz and a highfrequency (HF: 0.8−3.0 Hz) peaked at ~ 1 Hz. LF peak was abolished after verapamil infusion. The LF component of both spectra was observed to recover after continuous infusion of levosimendan. Additionally, a new frequency component was observed at 1.5 Hz in the spectrum of SBPV. Significant correlations were found between bands of the average spectra in both signals in all groups of treatment studied in this paper. Our results revealed that, like SBPV, SVV can herald useful information regarding the sympathovagal balance and cardiac output improvements.

References

  1. Brown, D., Brown, L., Patwardham, A., and Randall, D. (1994). Sympathetic activity and blood pressure are tightly coupled at 0.4 hz in conscious rats. Am J Physiol, 267(5 pt 2):R1378-84.
  2. Cerutti, C., Berrés, C., and Paultre, C. (1994). Baroreflex modulation of blood pressure and heart rate variabilities in rats: assessment by spectral analysis. Am J Physiol, 266(35):H1993-H2000.
  3. Fauchier, L., Babuty, D., Autret, M., Cosnay, P., and Fauchier, J. (1997). Effects of verapamil on heart rate variability in subjects with normal hearts. Am J Cardiol, 80(9):1234-5.
  4. Graudins, A., Najafi, J., and Perry, M. (2008). Treatment of experimental verapamil poisoning with levosimendan utilizing a rodent model of drug toxicity. Clin Toxicol, 46(1):50-6.
  5. Japundzic, N., Grichois, M., Zitoun, P., Laude, D., and Elghozi, J. (1990). Spectral analysis of blood pressure and heart rate in concious rats:effects of autonomic blockers. J Auton Nerv Syst, 30(2):91-100.
  6. Julien, C., Chapuis, B., Cheng, Y., and Barrés, C. (2003). Dynamic interactions between arterial pressure and sympathetic nerve activity: role of arterial baroreceptors. Am J Physiol Regul Integr Comp Physiol, 285(4):R834-41.
  7. Kouchoukos, N., Sheppard, L., and McDonald, D. (1970). Estimation of stroke volume in the dog by a pulse contour method. Circulation Research, 26(5):611-23.
  8. Liu, H., Yambe, T., Sasada, H., Nanka, S., Tanaka, A., Nagatomi, R., and Nitta, S. (2004). Comparison of heart rate variability and stroke volume variability. Auton Neuro: Basic and Clinical, 116(1-2):69-75.
  9. Moody, G., Mark, R., Zong, W., and Heldt, T. (2003). An open-source algorithm to detect onset of blood pressure pulses. IEEE Computers in Cardiology, 30:259- 262.
  10. Pinar, E., García-Alberola, E., LIamas, C., Vicente, T., L ópez-Candel, J., Rojo, J., Fernández, R., and Valdés, M. (1998). Effects of verapamil on indexes of heart rate variability after acute myocardial infarction. Am J Card, 81(9):1085-9.
  11. Sahin, I., Kosar, F., Altunkan, S., and Günaydin, M. (2004). Comparison of the effects of amlodipine and verapamil on autonomic activity in hypertensive patients. Eur J Intern, 15(4):225-230.
  12. Siebert, J., Drabik, P., Lango, R., and Szyndler, K. (2004). Stroke volume variability and heart rate power spectrum in relation to posture changes in healthy subjects. Med Sci Monit, 10(2):MT31-7.
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Paper Citation


in Harvard Style

H. AlOmari A., Graudins A. and V. Savkin A. (2009). THE POWER SPECTRA RESPONSE OF STROKE VOLUME AND ARTERIAL BLOOD PRESSURE VARIABILITY SIGNALS TO AUTONOMIC NERVOUS SYSTEM MODULATION OF THE HEART . In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2009) ISBN 978-989-8111-65-4, pages 411-415. DOI: 10.5220/0001775804110415


in Bibtex Style

@conference{biosignals09,
author={Abdul-Hakeem H. AlOmari and Andis Graudins and Andrey V. Savkin},
title={THE POWER SPECTRA RESPONSE OF STROKE VOLUME AND ARTERIAL BLOOD PRESSURE VARIABILITY SIGNALS TO AUTONOMIC NERVOUS SYSTEM MODULATION OF THE HEART},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2009)},
year={2009},
pages={411-415},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001775804110415},
isbn={978-989-8111-65-4},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2009)
TI - THE POWER SPECTRA RESPONSE OF STROKE VOLUME AND ARTERIAL BLOOD PRESSURE VARIABILITY SIGNALS TO AUTONOMIC NERVOUS SYSTEM MODULATION OF THE HEART
SN - 978-989-8111-65-4
AU - H. AlOmari A.
AU - Graudins A.
AU - V. Savkin A.
PY - 2009
SP - 411
EP - 415
DO - 10.5220/0001775804110415