MICROFLUIDIC CELL STIMULATOR USING BEAD IMPACT

Young-Hun Kim, Tae-Jin Kim, Hyung-Joon Kim, Min-Suk Park, Hyo-Il Jung

Abstract

Recently many researchers are focused on cell stimulation regarding observation of cells to specific stimulation factors. We introduce new mechanical stimulation method using micro beads without any chemical reagents. CPAE (calf pulmonary artery endothelial cell) were cultured in PDMS (polydimethylsiloxane) microfluidic device. After starvation process, sterilized 10um glass beads were rolled by only gravitational force for 10 minute. To find optimal stimulation time, 16 devices were made by PDMS and each device was slanted every hour. Results show that cell exposed under micro bead stimulation perform at a higher growth rate than normal conditions and 1 hour stimulation time represents more effective than other stimulation times. This new cell stimulation method will be able to help make artificial organ such as blood vessels in the future.

References

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Paper Citation


in Harvard Style

Kim Y., Kim T., Kim H., Park M. and Jung H. (2009). MICROFLUIDIC CELL STIMULATOR USING BEAD IMPACT . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2009) ISBN 978-989-8111- 64-7, pages 426-429. DOI: 10.5220/0001780204260429


in Bibtex Style

@conference{biodevices09,
author={Young-Hun Kim and Tae-Jin Kim and Hyung-Joon Kim and Min-Suk Park and Hyo-Il Jung},
title={MICROFLUIDIC CELL STIMULATOR USING BEAD IMPACT},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2009)},
year={2009},
pages={426-429},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001780204260429},
isbn={978-989-8111- 64-7},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2009)
TI - MICROFLUIDIC CELL STIMULATOR USING BEAD IMPACT
SN - 978-989-8111- 64-7
AU - Kim Y.
AU - Kim T.
AU - Kim H.
AU - Park M.
AU - Jung H.
PY - 2009
SP - 426
EP - 429
DO - 10.5220/0001780204260429