MODEL DEVELOPMENT FOR PROPOFOL AND REMIFENTANIL MANAGEMENT DURING ICU ANESTHESIA

Ramona Hodrea, Sandra Iulianetti, Clara Ionescu, Robin De Keyser

Abstract

This paper presents the development of a MISO (multiple-input single-output) patient model for sedation and analgesia components used in ICU. The two inputs are Propofol and Remifentanil and the output is the Bispectral Index. The MISO model consists of two well-known PK-PD models for Propofol and Remifentanil, and an interaction model which describes the synergistic effect of these two drugs on the Bispectral Index. The interaction model parameters were identified using a nonlinear least squares method. Data collected during clinical trials in ICU at Ghent University Hospital have been used for model development. The final purpose is to use this model for prediction in a model based predictive control strategy.

References

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Paper Citation


in Harvard Style

Hodrea R., Iulianetti S., Ionescu C. and De Keyser R. (2010). MODEL DEVELOPMENT FOR PROPOFOL AND REMIFENTANIL MANAGEMENT DURING ICU ANESTHESIA . In Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2010) ISBN 978-989-674-018-4, pages 145-150. DOI: 10.5220/0002591101450150


in Bibtex Style

@conference{biosignals10,
author={Ramona Hodrea and Sandra Iulianetti and Clara Ionescu and Robin De Keyser},
title={MODEL DEVELOPMENT FOR PROPOFOL AND REMIFENTANIL MANAGEMENT DURING ICU ANESTHESIA },
booktitle={Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2010)},
year={2010},
pages={145-150},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0002591101450150},
isbn={978-989-674-018-4},
}


in EndNote Style

TY - CONF
JO - Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2010)
TI - MODEL DEVELOPMENT FOR PROPOFOL AND REMIFENTANIL MANAGEMENT DURING ICU ANESTHESIA
SN - 978-989-674-018-4
AU - Hodrea R.
AU - Iulianetti S.
AU - Ionescu C.
AU - De Keyser R.
PY - 2010
SP - 145
EP - 150
DO - 10.5220/0002591101450150