A MORPHING TECHNIQUE TO ESTIMATE LUNG CANCER DEFORMATION DUE TO BREATHING IN RADIOTHERAPIC TREATMENT

Grazia Maria Pia Masselli, Luigi Battista, Sergio Silvestri, Sara Ramella, Lucio Trodella

Abstract

A morphing technique aimed to correlate lung cancer patient’s chest cross circumference variations with tumor morphology during quiet respiration is here described. Two CT slices corresponding to the same tumor section are acquired at forced inspiration and forced expiration and correlated with chest circumference values. An image sequence has been obtained by applying a linear morphing transformation. Each image of the sequence has been associated with a chest circumferential value and a sequence subset images corresponding to subject’s tidal volume has then been selected and compared with a CT slice acquired at tidal volume. Images showing the minimum pixel differences with slice at tidal volume were identified and associated with chest circumference values, allowing to estimate in which phase of the breathing period the CT scan was carried out. CT exams in free-breathing and breath-hold conditions have been conducted on a lung cancer patient in order to correlate the acquired slices with the variations of patient’s chest circumference measured with a pneumatic strain gauge. The here described methodology could allow to define the area to be irradiated during a particular phase of the breathing period, considering the cancer area in the morphing simulation frame corresponding to this phase as target.

References

  1. Webb, S. (2006) 'Motion effects in (intensity modulated) radiation therapy: a review', Phys. Med. Biol., vol. 51, pp. R403-R425.
  2. ICRU Report 50 (1993) Available: http://www.aitro.it/public/Crs100icru.pdf [20 Mar 2009].
  3. Lujian, A. E., Larsen, E. W., Balter, J. M., Haken, R. K. T. (1999) 'A method for incorporating organ motion into 3D dose calculations', Med. Phys., vol. 26, pp. 715-720.
  4. Wu, H., Sharp, G. C., Saltzberg, B., Kaeli, D., Shirato, H., Jang, S. B. (2004) 'A finite state model for respiratory motion analysis in image guided radiation therapy', Phys. Med. Biol., vol. 49, pp. 5357-5372.
  5. Report 91 del AAPM Task Group 76 (2006) 'The management of respiratory motion in radiation oncology', American Association of Physicists in Medicine.
  6. Murphy, M. J., Balter, J., Balter, S., BenComo, J. A. Jr, Das, I. J., Jiang, S. B., Ma, C. M., Olivera, G. H., Rodebaugh, R. F., Ruchala, K. J., Shirato, H., Yin, F. F. (2007) 'The management of imaging dose during image-guided radiotherapy: report of the AAPM Task Group 7578, Med. Phys., vol. 34, pp. 4041-4063.
  7. Mageras, G. S., Yorke, E. (2004) 'Deep inspiration breath hold and respiratory gating strategies for reducing organ motion in radiation treatment', Semin. Radiat. Oncol., vol. 14, pp. 65-75.
  8. Keall, P. J., Mageras, G. S., Balter, J. M., Emery, R. S., Forster, K. M., Jiang, S. B., Kapatoes, J. M., Low, D. A., Murphy, M. J., Murray, B. R., Ramsey, C. R., Van Herk, M. B., Vedam, S. S., Wong, J. W., Yorke, E. (2006) 'The management of respiratory motion in radiation oncology report of AAPM Task Group 7678, Med. Phys., vol. 33, pp. 3874-3900.
  9. Masselli, G. M. P., Silvestri, S., Ramella, S., Trodella, L. (2009) 'Design and evaluation of a methodology to perform personalized visual biofeedback for reducing respiratory amplitude in radiation treatment', Med. Phys., vol. 35, no. 5, pp. 1467-1472.
  10. George, R., Chung, T. D., Vedam, S. S., Ramakrishnan, V., Mohan, R., Weiss, E., Keall, P. J. (2006) 'Audiovisual biofeedback for respiratory-gated radiotherapy: impact of audio instruction and audio-visual biofeedback on respiratory-gated radiotherapy', Int. J. Radiat. Oncol. Biol. Phys., vol. 65, pp. 924-933.
  11. Briere, T., Jhaveri, P., Krishnan, S., Crane, C., Balter, P., Gillin, M., Mohan, R., Beddar, A. (2006) 'SU-FF-T114: Breath Coaching with Visual Feedback for EndExpiratory Gated Radiotherapy', Med. Phys., vol. 33, p. 2075.
  12. Venkat, R. B., Sawant, A., Suh, Y., George, R., Keall, P. J. (2008) 'Development and preliminary evaluation of a prototype audiovisual biofeedback device incorporating a patient-specific guiding waveform', Phys. Med. Biol., vol. 53, pp. N197-N208.
  13. Deurloo, K. E. I., Steenbakkers, R. H. M., Zijp L. J. et al. (2005) 'Quantification of shape variation of prostate and seminal vesicles during external beam radiotherapy', Int. J. Radiation Oncology Biol. Phys., vol. 61, pp. 228-238.
  14. Gomes, J., Darsa, L., Costa, B., Velho, L. (1999) 'Warping and Morphing of Graphical Objects', Morgan Kaufmann Editor.
  15. http://www.stoik.com/ [25 Mar 2009].
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Paper Citation


in Harvard Style

Maria Pia Masselli G., Battista L., Silvestri S., Ramella S. and Trodella L. (2010). A MORPHING TECHNIQUE TO ESTIMATE LUNG CANCER DEFORMATION DUE TO BREATHING IN RADIOTHERAPIC TREATMENT . In Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2010) ISBN 978-989-674-018-4, pages 363-366. DOI: 10.5220/0002591203630366


in Bibtex Style

@conference{biosignals10,
author={Grazia Maria Pia Masselli and Luigi Battista and Sergio Silvestri and Sara Ramella and Lucio Trodella},
title={A MORPHING TECHNIQUE TO ESTIMATE LUNG CANCER DEFORMATION DUE TO BREATHING IN RADIOTHERAPIC TREATMENT},
booktitle={Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2010)},
year={2010},
pages={363-366},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0002591203630366},
isbn={978-989-674-018-4},
}


in EndNote Style

TY - CONF
JO - Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2010)
TI - A MORPHING TECHNIQUE TO ESTIMATE LUNG CANCER DEFORMATION DUE TO BREATHING IN RADIOTHERAPIC TREATMENT
SN - 978-989-674-018-4
AU - Maria Pia Masselli G.
AU - Battista L.
AU - Silvestri S.
AU - Ramella S.
AU - Trodella L.
PY - 2010
SP - 363
EP - 366
DO - 10.5220/0002591203630366