RELEVANCE AND LOCI OF ODORANT FEATURES IN THE RAT OLFACTORY BULB - Statistical Methods for Understanding Olfactory Codes in Glomerular Images

Benjamin Auffarth, Agustín Gutierrez–Galvez, Santiago Marco

Abstract

The relationship between physicochemical properties of odor molecules and perceived odor quality is arguably one of the most important issues in olfaction and the rules governing this relationship remain unknown. Any given odor molecule will stimulate more than one type of receptor in the nose, perhaps hundreds, and this stimulation reflects itself in the neural code of the olfactory nervous system. We present a method to investigate neural coding at the glomerular level of the olfactory bulb, the first relay for olfactory processing in the brain. Our results give insights into localization of coding sites, relevance of odorant properties for information processing, and the size of coding zones.

References

  1. Axel, R. (1995). The molecular logic of smell. Sci Am, 273(4):154-9.
  2. Bozza, T., Feinstein, P., Zheng, C., and Mombaerts, P. (2002). Odorant Receptor Expression Defines Functional Units in the Mouse Olfactory System. Journal of Neuroscience, 22(8):3033-43.
  3. Buck, L. and Axel, R. (1991). A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell, 65(1):175-187.
  4. Cleland, T., Morse, A., Yue, E., and Linster, C. (2002). Behavioral models of odor similarity. Behavioral neuroscience, 116(2):222-231.
  5. Efron, B. (1982). The Jackknife, the Bootstrap and other resampling plans. In CBMS-NSF Regional Conference Series in Applied Mathematics, Philadelphia: Society for Industrial and Applied Mathematics (SIAM), 1982.
  6. Felsenstein, J. (1985). Confidence limits on phylogenies: an approach using the bootstrap. Evolution, pages 783- 791.
  7. Johnson, B., Xu, Z., Pancoast, P., Kwok, J., Ong, J., and Leon, M. (2006). Differential specificity in the glomerular response profiles for alicyclic, bicyclic and heterocyclic odorants. The Journal of comparative neurology, 499(1):1-16.
  8. Johnson, B. A., Arguello, S., and Leon, M. (2007). Odorants with multiple oxygen-containing functional groups and other odorants with high water solubility preferentially activate posterior olfactory bulb glomeruli. Journal of Comparative Neurology, 502(3):468-482.
  9. Johnson, B. A. and Leon, M. (2000). Odorant molecular length: One aspect of the olfactory code. Journal of Comparative Neurology, 426(2):330-338.
  10. Johnson, B. A. and Leon, M. (2007). Chemotopic odorant coding in a mammalian olfactory system. Journal of Comparative Neurology, 503:1-34.
  11. Johnson, B. A., Woo, C. C., Hingco, E. E., Pham, K. L., and Leon, M. (1999). Multidimensional chemotopic responses to n-aliphatic acid odorants in the rat olfactory bulb. Journal of Comparative Neurology, 409(4):529- 548.
  12. Johnson, B. A., Woo, C. C., and Leon, M. (1998). Spatial coding of odorant features in the glomerular layer of the rat olfactory bulb. Journal of Comparative Neurology, 393(4):457-471.
  13. Laughlin, S. and Sejnowski, T. (2003). Communication in neuronal networks. Science, 301(5641):1870-1874.
  14. Limpert, E., Stahel, W., and Abbt, M. (2001). Log-normal distributions across the sciences: keys and clues. Bioscience, 51(5):341-352.
  15. Malnic, B., Hirono, J., Sato, T., and Buck, L. (1999). combinatorial receptor codes for odors. Cell, 96(5):713- 723.
  16. Mori, K. and Shepherd, G. (1994). Emerging principles of molecular signal processing by mitral/tufted cells in the olfactory bulb. Semin Cell Biol, 5(1):65-74.
  17. Mori, K., Takahashi, Y., Igarashi, K., and Yamaguchi, M. (2006). Maps of odorant molecular features in the mammalian olfactory bulb. Physiological reviews, 86(2):409-433.
  18. Sell, C. (2006). On the unpredictability of odor. Angewandte Chemie International Edition, 45(38):6254- 6261.
  19. Uchida, N., Takahashi, Y., Tanifuji, M., and Mori, K. (2000). Odor maps in the mammalian olfactory bulb: domain organization and odorant structural features. Nature Neuroscience, 3:1035-1043.
  20. Wand, M. P. (1997). Data-based choice of histogram bin width. The American Statistician, 51(1):59-64.
  21. Yoshida, I. and Mori, K. (2007). Odorant Category Profile Selectivity of Olfactory Cortex Neurons. Journal of Neuroscience, 27(34):9105-9114.
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Paper Citation


in Harvard Style

Auffarth B., Gutierrez–Galvez A. and Marco S. (2010). RELEVANCE AND LOCI OF ODORANT FEATURES IN THE RAT OLFACTORY BULB - Statistical Methods for Understanding Olfactory Codes in Glomerular Images . In Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2010) ISBN 978-989-674-018-4, pages 37-44. DOI: 10.5220/0002697200370044


in Bibtex Style

@conference{biosignals10,
author={Benjamin Auffarth and Agustín Gutierrez–Galvez and Santiago Marco},
title={RELEVANCE AND LOCI OF ODORANT FEATURES IN THE RAT OLFACTORY BULB - Statistical Methods for Understanding Olfactory Codes in Glomerular Images},
booktitle={Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2010)},
year={2010},
pages={37-44},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0002697200370044},
isbn={978-989-674-018-4},
}


in EndNote Style

TY - CONF
JO - Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2010)
TI - RELEVANCE AND LOCI OF ODORANT FEATURES IN THE RAT OLFACTORY BULB - Statistical Methods for Understanding Olfactory Codes in Glomerular Images
SN - 978-989-674-018-4
AU - Auffarth B.
AU - Gutierrez–Galvez A.
AU - Marco S.
PY - 2010
SP - 37
EP - 44
DO - 10.5220/0002697200370044