ELECTRICAL CHARACTERIZATION OF SEQUENCE-SPECIFIC LABEL-FREE DNA BY USING POLYSILICON WIRE

You-Lin Wu, Po-Yen Hsu, Chung-Ping Hsu, Wen- Cheng Liu

Abstract

In this paper we report the electrical measurement of sequence-specific and label-free deoxyribonucleic acid (DNA) by using poly-silicon (poly-Si) wire. Four single-strained (ss) DNA bases, adenine (A), thymine (T), cytosine (C) and guanines (G), as well as double-stranded (ds) DNA sequences, ds(A-T) and ds(C-G), with different lengths and concentrations were dropped onto the poly-Si wire surface, and currents flowing through the poly-Si wire channel were determined. It is found that the amount change of the channel current I for ssDNAs with fixed length and fixed concentration is that T > C > G > A. For dsDNA sequence, we observe that ds(A-T) has higher I than does ds(C-G). We also prove that single base change in ssDNA is feasible by using the poly-Si wire sensor.

References

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Paper Citation


in Harvard Style

Wu Y., Hsu P., Hsu C. and Liu W. (2010). ELECTRICAL CHARACTERIZATION OF SEQUENCE-SPECIFIC LABEL-FREE DNA BY USING POLYSILICON WIRE . In Proceedings of the Third International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2010) ISBN 978-989-674-017-7, pages 170-173. DOI: 10.5220/0002712601700173


in Bibtex Style

@conference{biodevices10,
author={You-Lin Wu and Po-Yen Hsu and Chung-Ping Hsu and Wen- Cheng Liu},
title={ELECTRICAL CHARACTERIZATION OF SEQUENCE-SPECIFIC LABEL-FREE DNA BY USING POLYSILICON WIRE},
booktitle={Proceedings of the Third International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2010)},
year={2010},
pages={170-173},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0002712601700173},
isbn={978-989-674-017-7},
}


in EndNote Style

TY - CONF
JO - Proceedings of the Third International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2010)
TI - ELECTRICAL CHARACTERIZATION OF SEQUENCE-SPECIFIC LABEL-FREE DNA BY USING POLYSILICON WIRE
SN - 978-989-674-017-7
AU - Wu Y.
AU - Hsu P.
AU - Hsu C.
AU - Liu W.
PY - 2010
SP - 170
EP - 173
DO - 10.5220/0002712601700173