IN SILICO STUDY OF EXPRESSION PROFILES CORRELATION BETWEEN MICRORNAS AND CANCEROUS GENES

Ka-Lok Ng, Chia-Wei Weng

Abstract

We investigate the possibility that microRNA can act as an oncogene or tumor suppressor gene. Experimentally verified microRNA target genes information (TarBase) are integrated with microRNA and mRNA expression data (NCI-60) to study this hypothesis, in which the Pearson correlation and Spearman rank coefficients are used to quantify these relations for nine cancer types. Correlation coefficients with negative values are used to filter out microRNA targets. Biological annotations of the targets are supplied by using the TAG, GO and KEGG records. The above information are utilized to provide a platform in identifying potential cancer related microRNAs. A web based interface is set up for information query and data display.

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Paper Citation


in Harvard Style

Ng K. and Weng C. (2010). IN SILICO STUDY OF EXPRESSION PROFILES CORRELATION BETWEEN MICRORNAS AND CANCEROUS GENES . In Proceedings of the First International Conference on Bioinformatics - Volume 1: BIOINFORMATICS, (BIOSTEC 2010) ISBN 978-989-674-019-1, pages 141-146. DOI: 10.5220/0002728701410146


in Bibtex Style

@conference{bioinformatics10,
author={Ka-Lok Ng and Chia-Wei Weng},
title={IN SILICO STUDY OF EXPRESSION PROFILES CORRELATION BETWEEN MICRORNAS AND CANCEROUS GENES},
booktitle={Proceedings of the First International Conference on Bioinformatics - Volume 1: BIOINFORMATICS, (BIOSTEC 2010)},
year={2010},
pages={141-146},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0002728701410146},
isbn={978-989-674-019-1},
}


in EndNote Style

TY - CONF
JO - Proceedings of the First International Conference on Bioinformatics - Volume 1: BIOINFORMATICS, (BIOSTEC 2010)
TI - IN SILICO STUDY OF EXPRESSION PROFILES CORRELATION BETWEEN MICRORNAS AND CANCEROUS GENES
SN - 978-989-674-019-1
AU - Ng K.
AU - Weng C.
PY - 2010
SP - 141
EP - 146
DO - 10.5220/0002728701410146