STUDY OF EFFECTIVE CONNECTIVITY FOR FACE PERCEPTION IN HEALTHY SUBJECTS AND PARKINSON'S DISEASE

Elvis Lira da Silva, Gabriela Castellano, João Ricardo Sato, Ellison Fernando Cardoso, Edson Amaro Jr.

Abstract

Facial perception is a fundamental task in our daily life and plays a critical role in social interactions. Evidence from neuropsychological, neurophysiologic, and functional imaging studies indicated that face perception is mediated by a specialized system in the human brain. We investigated the neural connectivity induced by face presentation with different emotional valences in Parkinson's disease (PD) patients and a control group of healthy, drug-free volunteers, using event-related fMRI in a parametric design. In this study, we focused on applying Dynamic Causal Modelling (DCM), an approach that allows the assessment of effective connectivity within cortical networks (Friston et al. 2003), to the study of effective connectivity between maximally activated brain regions in response to passive viewing of facial stimuli. A connectivity model was built based on the literature and in our fMRI analyses, which included the fusiform gyrus, anterior cingulate gyrus, dorsolateral prefrontal cortex (DLPFC) and dorsomedial prefrontal cortex (DMPFC). The results showed differences in connectivity between the PD group and the control group. We found that the effective couplings among DLPFC/DMPFC and FG, DLPFC/DMPFC and ACG, were higher in PD patients than healthy subjects, while the effective coupling among FG and ACG was lower in PD patients.

References

  1. Assogna F. , Pontieri F., Caltagirone C., Spalletta G. 2008. The recognition of facial emotion expressions in Parkinson's disease. European Neuropsychopharmacology 18, 835-848.
  2. Dujardin K., Blairy S., Defebvre L.,, Duhemb S., Noël Y, Hess U., Destée A. 2004. Deficits in decoding emotional facial expressions in Parkinson's disease. Neuropsychologia 42, 239-250
  3. Cardoso, E., Fregni F., Maia F., Boggio, P., Myczkowski, M., Coracini K., Vieira A., Melo L., Sato, J., Marcolin M., Rigonatti S., Cruz A.,Barbosa, E. and Amaro, E., 2007. rTMS treatment for depression in Parkinson's disease increases BOLD responses in the left refrontal cortex. International Journal of Neuropsychopharmacology, 11(2), 173 - 183.
  4. Fairhall, S. and Ishai, A., 2007. Effective Connectivity within the Distributed Cortical Network for Face Perception. Cerebral Cortex, 17(10), 2400-2406.
  5. Friston, K., Harrison, L., Penny, W., 2003. Dynamic causal modeling. NeuroImage 19, 1273- 1302.
  6. Fu C., Williams S., Cleare A., Brammer M., Walsh N., Kim J., Andrew C., Pich E., Williams P., Reed L., et al. 2004. Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study. Archives of General Psychiatry 61, 877-889
  7. Haxby, J., Hoffman, E., Gobbini, M., 2000. The distributed human neural system for face perception. Trends in Cognitive Sciences, 4(6), 223-233.
  8. Mechelli A., Price C., Friston K., Ishai A., 2004. Where bottom-up meets top-down: neuronal interactions during perception and imagery. Cerebral Cortex. 14, 1256-1265.
  9. Maldjian, J., Laurienti, P., Burdette, J., Kraft, R., 2003. An Automated Method for Neuroanatomic and Cytoarchitectonic Atlas-based Interrogation of fMRI Data Sets. NeuroImage, 19, 1233-1239.
  10. Maldjian, J., Laurienti, P., Burdette, J., 2004. Precentral Gyrus Discrepancy in Electronic Versions of the Talairach Atlas. Neuroimage, 21(1), 450-455.
  11. Phillips M., Drevets W., Rauch S., Lane R., 2003a. Neurobiology of emotion perception I: The neural basis of normal emotion perception. Biological Psychiatry 54, 504-514.
  12. Phillips M., Drevets W., Rauch S., Lane R., 2003b. Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biological Psychiatry 54, 515-528.
  13. Rotshtein P., Vuilleumier P., Winston J., Driver J., Dolan R., 2007. Distinct and convergent visual processing of high and low spatial frequency information in faces. Cerebral Cortex 17, 2713-2724.
  14. Sprengelmeyer R., Young A., Mahna K., Schroeder U. , Woitalla D., Büttner T. , Kuhn W. , Przuntek H. 2003. Facial expression recognition in people with medicated and unmedicated Parkinson's disease. Neuropsychologia 41, 1047-1057.
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Paper Citation


in Harvard Style

Lira da Silva E., Castellano G., Ricardo Sato J., Fernando Cardoso E. and Amaro Jr. E. (2010). STUDY OF EFFECTIVE CONNECTIVITY FOR FACE PERCEPTION IN HEALTHY SUBJECTS AND PARKINSON'S DISEASE . In Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2010) ISBN 978-989-674-018-4, pages 88-93. DOI: 10.5220/0002743800880093


in Bibtex Style

@conference{biosignals10,
author={Elvis Lira da Silva and Gabriela Castellano and João Ricardo Sato and Ellison Fernando Cardoso and Edson Amaro Jr.},
title={STUDY OF EFFECTIVE CONNECTIVITY FOR FACE PERCEPTION IN HEALTHY SUBJECTS AND PARKINSON'S DISEASE},
booktitle={Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2010)},
year={2010},
pages={88-93},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0002743800880093},
isbn={978-989-674-018-4},
}


in EndNote Style

TY - CONF
JO - Proceedings of the Third International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2010)
TI - STUDY OF EFFECTIVE CONNECTIVITY FOR FACE PERCEPTION IN HEALTHY SUBJECTS AND PARKINSON'S DISEASE
SN - 978-989-674-018-4
AU - Lira da Silva E.
AU - Castellano G.
AU - Ricardo Sato J.
AU - Fernando Cardoso E.
AU - Amaro Jr. E.
PY - 2010
SP - 88
EP - 93
DO - 10.5220/0002743800880093