THE ROLE OF THREE-DIMENSIONAL SCAFFOLDS IN THE REGENERATION OF JOINT CARTILAGE

J. L. Gómez Ribelles, M. Monleón Pradas, R. García Gómez, F. Forriol, M. Sancho-Tello, C. Carda

Abstract

A variety of polymer scaffolds with pore architecture consisting of interconnected spherical pores with the same architecture but varying mechanical properties (in particular elastic modulus), water sorption capacity, pore surface characteristics (surface tension, presence of hydrophilic groups or electric charges) was prepared and implanted in a 3mm diameter full thickness defects in the knee joint cartilage of rabbits in order to show the influence of the scaffold properties on the histological characteristics of the regenerated tissue.

References

  1. Brígido Diego R., Pérez Olmedilla M., Serrano Aroca A., Gómez Ribelles J.L., Monleón Pradas M., Gallego Ferrer G., Salmerón Sánchez M. Acrylic scaffolds with interconnected spherical pores and controlled hydrophilicity for tissue engineering. J.Mat. Sci. Mat. Medicine (2005) 16, 693-698
  2. Brígido Diego R., Gómez Ribelles J.L., Salmerón Sánchez M. On the pore collapse during the fabrication process of rubber-like polymer scaffolds. J. Appl. Polym. Sci. (2007) 104, 1475-1481.
  3. Brittberg M., Peterson L., Sjögren-Jansson E,, Tallheden T., Lindahl A. Articular cartilage engineering with autologous chondrocyte transplantation. A review of recent developments.The Journal of bone and joint surgery. American volume (2003) 85-A,109-115
  4. Chen V.J., Ma P.X. Nano-fibrous poly(L-lactic acid) scaffolds with interconnected spherical macropores. Biomaterials (2004) 25, 2065-2073.
  5. Ma Z., Gao C., Gong Y., Shen J. Paraffin spheres as porogen to fabricate poly(L-lactic acid) scaffolds with improved cytocompatibility for cartilage tissue engineering. Journal of biomedical materials research. Part B, Applied biomaterials (2003) 67, 610-617.
  6. Marlovits S., Zeller P., Singer P., Resinger C., Vilmos Vécsei V. Cartilage repair: Generations of autologous chondrocyte transplantation. European Journal of Radiology (2006) 57, 24-31
  7. Shoichet M.S., Hubbell J.A. (ed) Polymers in Tissue Engineering. VSP, Utrech (1998)
  8. Smith G.D., Knutsen G., Richardson J.B., A clinical review of cartilagerepair techniques J. Bone and Joint Surgery (2005) 87, 445-449.
  9. Steadman J.R., Rodkey W.G., Briggs K.K., Rodrigo J.J. The microfracture technic in the management of complete cartilage defects in the knee joint. Orthopade (1999) 28, 26-32.
Download


Paper Citation


in Harvard Style

L. Gómez Ribelles J., Monleón Pradas M., García Gómez R., Forriol F., Sancho-Tello M. and Carda C. (2010). THE ROLE OF THREE-DIMENSIONAL SCAFFOLDS IN THE REGENERATION OF JOINT CARTILAGE . In Proceedings of the Third International Conference on Biomedical Electronics and Devices - Volume 1: Special Session RAPID-Bio, (BIOSTEC 2010) ISBN 978-989-674-017-7, pages 229-234. DOI: 10.5220/0002765102290234


in Bibtex Style

@conference{special session rapid-bio10,
author={J. L. Gómez Ribelles and M. Monleón Pradas and R. García Gómez and F. Forriol and M. Sancho-Tello and C. Carda},
title={THE ROLE OF THREE-DIMENSIONAL SCAFFOLDS IN THE REGENERATION OF JOINT CARTILAGE },
booktitle={Proceedings of the Third International Conference on Biomedical Electronics and Devices - Volume 1: Special Session RAPID-Bio, (BIOSTEC 2010)},
year={2010},
pages={229-234},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0002765102290234},
isbn={978-989-674-017-7},
}


in EndNote Style

TY - CONF
JO - Proceedings of the Third International Conference on Biomedical Electronics and Devices - Volume 1: Special Session RAPID-Bio, (BIOSTEC 2010)
TI - THE ROLE OF THREE-DIMENSIONAL SCAFFOLDS IN THE REGENERATION OF JOINT CARTILAGE
SN - 978-989-674-017-7
AU - L. Gómez Ribelles J.
AU - Monleón Pradas M.
AU - García Gómez R.
AU - Forriol F.
AU - Sancho-Tello M.
AU - Carda C.
PY - 2010
SP - 229
EP - 234
DO - 10.5220/0002765102290234