LOW-INVASIVE HEATING AND TEMPERATURE MEASUREMENT METHOD FOR HYPERTHERMIA TREATMENT USING THE METAL COATED FERROMAGNETIC IMPLANT WITH LOW CURIE TEMPERATURE

Kazutaka Mitobe, Noboru Yoshimura

Abstract

Hyperthermia has been used for many years to treat various types of malignant tumor because tumor cells are more sensitive to temperature in the range of 42-45°C than are normal tissue cells. In this study, we aim to develop the local heating method and monitoring method for hyperthermia using the Ferromagnetic Implant with Low Curie Temperature (FILCT) under high frequency magnetic field. The heat generation inefficiency of FILCT causes a barrier in order to use this method as a bedside tool. In this research work, we coated the FILCT with a metal material in order to improve the heat generation efficiency. The magnetic permeability of FILCT decreased around the Curie temperature; therefore we can use FILCT as a thermal probe by measuring of the changing vector of the magnetic flux at the outside of human body noninvasively. In this paper, we describe about the experimental setup and in vitro experimental results.

References

  1. Abe M, Hiraoka M, Takahashi M et al., 1986. Multiinstitutional studies on hyperthermia using an 8-MHz radiofrequency capacitive heating device (Thermotron RF-8) in combination with radiation for cancer therapy. Cancer, vol.58, pp.1589-95.
  2. Cavaliere, R., Ciocatto, EC., Giovanella, BC., et al. 1967. Selective heat sensitivity of cancer cells. Biochemical and clinical studies. Cancer, vol.20, pp.1351-1381.
  3. Hiraoka M, Nishimura Y, Nagata Y et al., 1994. Sitespecific phase I, II trials of hyperthermia at Kyoto University. Int J Hyperthermia, Vol.10, pp.403-10.
  4. Ishida, T., Kato, H., Miyakoshi, J., Furukawa, M., Ohsaki, S. and Kano, E., 1980. Physical Basis of RF Hyperthermia for Cancer Therapy (1) Measurement for Distribution in Absorbed Power from Radiofrequency Exposure in Agar Phantom, J. Radiat. Res., vol.21, pp.180 -189.
  5. Ito, A., Saito, H., Mitobe, K., Minamiya, Y., Takahashi, N., Maruyama, K., Motoyama, S., Katayose, Y. and Ogawa, J., 2009. Inhibition of heat shock protein 90 sensitizes melanoma cells to thermosensitive ferromagnetic particle-mediated hyperthermia with low curie temperature, Cancer Science, vol.100, pp.558-64.
  6. Jordan, A., Wust, P., Fahling, H., John, W., Hinz, A. and Felix, R., 1993. Inductive heating of ferrimagnetic particles and magnetic fluids: physical evaluation of their potential for hyperthermia. Int J Hyperthermia, vol.9, pp.51-68.
  7. Matsuki, H., Murakami, K. and Niizuma, H., 1982. Soft Heating - A New Method of Heating Using Temperature-Sensitive Magnetic Cores, IEEE Trans. Magn, vol.MAG-18, pp.1788-1790.
  8. Mitobe, K. and Yoshimura, N., 2008. Noninvasive Temperature Measurement Method for Hyperthermia Treatment using Ferromagnetic Implant with Low Curie Temperature, 30th Annual Inter. Conf. IEEE EMBS, pp.4384-4386.
  9. Overgaard, K. and Overgaard, J., 1972. Investigations on the possibility of a thermic tumour therapy. I. Shortwave treatment of a transplanted isologous mouse mammary carcinoma. Eur J Cancer, Vol.8, pp.65-78.
  10. Saito, H., Mitobe, K., Ito, A., Sugawara, Y., Maruyama, K., Minamiya, Y., Motoyama, S., Yoshimura, N. and Ogawa, J., 2008. Self-regulating hyperthermia induced using thermosensitive ferromagnetic material having a low Curie temperature, Cancer Science, No.99, pp.805-809.
  11. Shinkai, M., Yanase, M., Honda, H., Wakabayashi, T., Yoshida, J. and Kobayashi, T., 1996. Intracellular hyperthermia for cancer using magnetite cationic liposomes in vitro study. Jpn J Cancer Res, vol.87, pp.1179-83.
Download


Paper Citation


in Harvard Style

Mitobe K. and Yoshimura N. (2011). LOW-INVASIVE HEATING AND TEMPERATURE MEASUREMENT METHOD FOR HYPERTHERMIA TREATMENT USING THE METAL COATED FERROMAGNETIC IMPLANT WITH LOW CURIE TEMPERATURE . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2011) ISBN 978-989-8425-37-9, pages 341-344. DOI: 10.5220/0003152803410344


in Bibtex Style

@conference{biodevices11,
author={Kazutaka Mitobe and Noboru Yoshimura},
title={LOW-INVASIVE HEATING AND TEMPERATURE MEASUREMENT METHOD FOR HYPERTHERMIA TREATMENT USING THE METAL COATED FERROMAGNETIC IMPLANT WITH LOW CURIE TEMPERATURE},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2011)},
year={2011},
pages={341-344},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003152803410344},
isbn={978-989-8425-37-9},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2011)
TI - LOW-INVASIVE HEATING AND TEMPERATURE MEASUREMENT METHOD FOR HYPERTHERMIA TREATMENT USING THE METAL COATED FERROMAGNETIC IMPLANT WITH LOW CURIE TEMPERATURE
SN - 978-989-8425-37-9
AU - Mitobe K.
AU - Yoshimura N.
PY - 2011
SP - 341
EP - 344
DO - 10.5220/0003152803410344