TOWARDS A STATISTICAL DESCRIPTION OF EXPERIMENTAL DATA FOR DETECTION-ESTIMATION PROBLEMS IN DNA TRANSLOCATIONS THROUGH NANOPORES

S. Michelet, J-P. Barbot, O. Francais, P-Y. Joubert, P. Larzabal, R. Kawano, H. Sasaki, T. Osaki, S. Takeuchi, B. Le Pioufle

Abstract

This paper investigates the properties of DNA translocations signals in a stochastic framework. The considered signals are relative to the translocation of single strand DNA through natural nanopores, and are obtained using a planar patch clamp method. The stochastic signal analysis is carried out considering the statistical distribution of DNA translocation parameters, considered as random variables including the amplitude, the duration and the apparition of the DNA translocation events as well as the no-translocation signal features. For each of these variables, a distribution function is proposed and assessed using a Kolmogorov-Smirnov test, and their features are estimated. The DNA translocation signal stochastic analysis enables to characterize the detection and/or estimation performances of existing algorithms, such as a breakdown detection algorithm, in a stochastic framework. Moreover, it opens the way to the design of model based algorithms such as detection tests using a likelihood ratio or joint detection-estimation algorithms using a maximum likelihood approach, for an enhanced characterization of DNA translocations.

References

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Paper Citation


in Harvard Style

Michelet S., Barbot J., Francais O., Joubert P., Larzabal P., Kawano R., Sasaki H., Osaki T., Takeuchi S. and Le Pioufle B. (2011). TOWARDS A STATISTICAL DESCRIPTION OF EXPERIMENTAL DATA FOR DETECTION-ESTIMATION PROBLEMS IN DNA TRANSLOCATIONS THROUGH NANOPORES . In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011) ISBN 978-989-8425-35-5, pages 221-226. DOI: 10.5220/0003160702210226


in Bibtex Style

@conference{biosignals11,
author={S. Michelet and J-P. Barbot and O. Francais and P-Y. Joubert and P. Larzabal and R. Kawano and H. Sasaki and T. Osaki and S. Takeuchi and B. Le Pioufle},
title={TOWARDS A STATISTICAL DESCRIPTION OF EXPERIMENTAL DATA FOR DETECTION-ESTIMATION PROBLEMS IN DNA TRANSLOCATIONS THROUGH NANOPORES},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011)},
year={2011},
pages={221-226},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003160702210226},
isbn={978-989-8425-35-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011)
TI - TOWARDS A STATISTICAL DESCRIPTION OF EXPERIMENTAL DATA FOR DETECTION-ESTIMATION PROBLEMS IN DNA TRANSLOCATIONS THROUGH NANOPORES
SN - 978-989-8425-35-5
AU - Michelet S.
AU - Barbot J.
AU - Francais O.
AU - Joubert P.
AU - Larzabal P.
AU - Kawano R.
AU - Sasaki H.
AU - Osaki T.
AU - Takeuchi S.
AU - Le Pioufle B.
PY - 2011
SP - 221
EP - 226
DO - 10.5220/0003160702210226