LITTER EFFECT IN MOUSE PHENOTYPIC STUDIES

Petr Simecek, Maria Dzur-Gejdosova, Irena Chvatalova, Jiri Forejt

Abstract

The laboratory mouse is the most common mammalian model organism for research of the human body functions and disorders. For experimental purposes mice selected from inbred strains, developed by many generations of brother-sister crosses, are usually used. Individual mice of a given inbred strain are therefore considered genetically identical. However, our preliminary observations suggest that for a number of phenotypic traits mice originating from the same litter are significantly more similar than mice coming from different litters of the same inbred strain. We estimated the size of this litter effect for a number of traits in several phenotypic studies. By means of simulation we showed that ignoring the litter effect may result in several fold higher false positive rate and severe underestimation of minimal sample size.

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Paper Citation


in Harvard Style

Simecek P., Dzur-Gejdosova M., Chvatalova I. and Forejt J. (2011). LITTER EFFECT IN MOUSE PHENOTYPIC STUDIES . In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2011) ISBN 978-989-8425-36-2, pages 238-243. DOI: 10.5220/0003173602380243


in Bibtex Style

@conference{bioinformatics11,
author={Petr Simecek and Maria Dzur-Gejdosova and Irena Chvatalova and Jiri Forejt},
title={LITTER EFFECT IN MOUSE PHENOTYPIC STUDIES},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2011)},
year={2011},
pages={238-243},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003173602380243},
isbn={978-989-8425-36-2},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2011)
TI - LITTER EFFECT IN MOUSE PHENOTYPIC STUDIES
SN - 978-989-8425-36-2
AU - Simecek P.
AU - Dzur-Gejdosova M.
AU - Chvatalova I.
AU - Forejt J.
PY - 2011
SP - 238
EP - 243
DO - 10.5220/0003173602380243