# EFFECT OF CORRELATION BETWEEN CLINICAL TESTS ON THE PERFORMANCE OF A MULTIPLE TEST-BASED DIAGNOSTIC SYSTEM - Study with a Logistic Model and Neural Nets

### Noriaki Ikeda, Kai Ishida, Harukazu Tsuruta, Akihiro Takeuchi

#### Abstract

To examine the improvement of diagnostic performance by combining multiple tests, an algorithm was developed for generation of simulated data with arbitrary sensitivity, specificity and inter-test correlations. The effects of the number of tests and inter-test correlations on the diagnostic performance were studied using a logistic model and neural network (NN) models. The diagnostic performance measured by the concordance index, c, increased as the number of tests increased. For the same number of tests, the diagnostic performance was lowered by positive correlation and was elevated by negative correlation. Improvement of the performance was not obtained by increasing the number of NN layers.

#### References

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#### Paper Citation

#### in Harvard Style

Ikeda N., Ishida K., Tsuruta H. and Takeuchi A. (2011). **EFFECT OF CORRELATION BETWEEN CLINICAL TESTS ON THE PERFORMANCE OF A MULTIPLE TEST-BASED DIAGNOSTIC SYSTEM - Study with a Logistic Model and Neural Nets** . In *Proceedings of the International Conference on Neural Computation Theory and Applications - Volume 1: NCTA, (IJCCI 2011)* ISBN 978-989-8425-84-3, pages 326-329. DOI: 10.5220/0003655703260329

#### in Bibtex Style

@conference{ncta11,

author={Noriaki Ikeda and Kai Ishida and Harukazu Tsuruta and Akihiro Takeuchi},

title={EFFECT OF CORRELATION BETWEEN CLINICAL TESTS ON THE PERFORMANCE OF A MULTIPLE TEST-BASED DIAGNOSTIC SYSTEM - Study with a Logistic Model and Neural Nets},

booktitle={Proceedings of the International Conference on Neural Computation Theory and Applications - Volume 1: NCTA, (IJCCI 2011)},

year={2011},

pages={326-329},

publisher={SciTePress},

organization={INSTICC},

doi={10.5220/0003655703260329},

isbn={978-989-8425-84-3},

}

#### in EndNote Style

TY - CONF

JO - Proceedings of the International Conference on Neural Computation Theory and Applications - Volume 1: NCTA, (IJCCI 2011)

TI - EFFECT OF CORRELATION BETWEEN CLINICAL TESTS ON THE PERFORMANCE OF A MULTIPLE TEST-BASED DIAGNOSTIC SYSTEM - Study with a Logistic Model and Neural Nets

SN - 978-989-8425-84-3

AU - Ikeda N.

AU - Ishida K.

AU - Tsuruta H.

AU - Takeuchi A.

PY - 2011

SP - 326

EP - 329

DO - 10.5220/0003655703260329