A REGISTRATION FRAMEWORK FOR EVALUATION OF T1, T2 AND DWI SIGNAL INTENSITIES IN MULTIPLE MYELOMA

Eros Montin, Paolo Potepan, Luca Mainardi

Abstract

Objective. In this study we point out the Diffusion-Weighted Imaging (DWI) role in the diagnosis of multiple myeloma (MM), comparing its signal values (SV) (Sommer et al., 2010) with the standard imaging modalities T1, T2. We further evaluate how SV change in relation with the percentage of plasma cells infiltration evaluated through bone marrow biopsy (BMB). Methods. Since March 2008 23 patients with average age of 61 (+/- 11) years old, 11 females and 12 males, have been investigated before their own therapy with a whole body MRI protocol, concerning a whole body T1, a whole body T2 and a whole body DWI and a BMB. An experienced radiologist defined for each patient two volume of interests (VOIs): onto the main lesions and on healthy bones (Femur and Homerus). After that, we have subdivided the full population by a clinical threshold of 25% on cells infiltration percentage; then, we analysed statistical differences in the 2 groups (A, B). Results. We found out that DWI voxels intensities in group A (infiltration <= 25%) were higher than group B, this gap had to be considered statistically different (P <= 0:05).

References

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Paper Citation


in Harvard Style

Montin E., Potepan P. and Mainardi L. (2012). A REGISTRATION FRAMEWORK FOR EVALUATION OF T1, T2 AND DWI SIGNAL INTENSITIES IN MULTIPLE MYELOMA . In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: MIAD, (BIOSTEC 2012) ISBN 978-989-8425-89-8, pages 563-566. DOI: 10.5220/0003777505630566


in Bibtex Style

@conference{miad12,
author={Eros Montin and Paolo Potepan and Luca Mainardi},
title={A REGISTRATION FRAMEWORK FOR EVALUATION OF T1, T2 AND DWI SIGNAL INTENSITIES IN MULTIPLE MYELOMA},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: MIAD, (BIOSTEC 2012)},
year={2012},
pages={563-566},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003777505630566},
isbn={978-989-8425-89-8},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: MIAD, (BIOSTEC 2012)
TI - A REGISTRATION FRAMEWORK FOR EVALUATION OF T1, T2 AND DWI SIGNAL INTENSITIES IN MULTIPLE MYELOMA
SN - 978-989-8425-89-8
AU - Montin E.
AU - Potepan P.
AU - Mainardi L.
PY - 2012
SP - 563
EP - 566
DO - 10.5220/0003777505630566