CHARACTERIZATION OF THE ENCAPSULATION PROCESS OF DEEP BRAIN STIMULATION ELECTRODES USING IMPEDANCE SPECTROSCOPY IN A RODENT MODEL

K. Badstübner, T. Kröger, E. Mix, U. Gimsa, R. Benecke, J. Gimsa

Abstract

Deep brain stimulation (DBS) is effective for the treatment of patients with Parkinson’s disease (PD), especially in advanced stages which are refractory to conventional therapy. Despite of the regular use in clinical therapy, rodent models for basic research into DBS are not routinely available. The main reason is the geometry difference from rodents to humans, imposing larger problems in the transfer of the stimulation conditions than from primates to humans. For rodents, the development of miniaturized mobile stimulators and stimulation parameters, as well as improved electrode materials and geometry are desirable. The impedance of custom made, cylindrical (contact diameter 200 µm, length 100 µm), platinum/iridium electrodes has been measured in vivo for two weeks to characterize the influence of electrochemical processes and of the adherent cell growth at the electrode surface. During the encapsulation process, the real part of the electrode impedance at 10 kHz doubled with respect to its initial value after a characteristic decrease by approximately one third at the second day. An outlook is given on further investigations with different electrode designs for long-term DBS.

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Paper Citation


in Harvard Style

Badstübner K., Kröger T., Mix E., Gimsa U., Benecke R. and Gimsa J. (2012). CHARACTERIZATION OF THE ENCAPSULATION PROCESS OF DEEP BRAIN STIMULATION ELECTRODES USING IMPEDANCE SPECTROSCOPY IN A RODENT MODEL . In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2012) ISBN 978-989-8425-89-8, pages 125-130. DOI: 10.5220/0003790301250130


in Bibtex Style

@conference{biosignals12,
author={K. Badstübner and T. Kröger and E. Mix and U. Gimsa and R. Benecke and J. Gimsa},
title={CHARACTERIZATION OF THE ENCAPSULATION PROCESS OF DEEP BRAIN STIMULATION ELECTRODES USING IMPEDANCE SPECTROSCOPY IN A RODENT MODEL},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2012)},
year={2012},
pages={125-130},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003790301250130},
isbn={978-989-8425-89-8},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2012)
TI - CHARACTERIZATION OF THE ENCAPSULATION PROCESS OF DEEP BRAIN STIMULATION ELECTRODES USING IMPEDANCE SPECTROSCOPY IN A RODENT MODEL
SN - 978-989-8425-89-8
AU - Badstübner K.
AU - Kröger T.
AU - Mix E.
AU - Gimsa U.
AU - Benecke R.
AU - Gimsa J.
PY - 2012
SP - 125
EP - 130
DO - 10.5220/0003790301250130