IN-SITU SPECTROSCOPIC INVESTIGATION OF UNFOLDING AND AGGREGATION OF INSULIN UNDER ULTRASONIC EXCITATION - An Ultrasonic Actuator for FTIR-spectrometry on Biomatter

Helge Pfeiffer, Nikos Chatziathanasiou, Filip Meersman, Christ Glorieux, Karel Heremans, Martine Wevers

Abstract

It is well-known that fibrillogenesis of proteins can be influenced by diverse external parameters, such as temperature, pressure, agitation or chemical agents. This paper presents a newly developed ultrasonic actuator cell and a corresponding first feasibility study shows that also ultrasonic excitation at moderate intensities has a clear influence on the unfolding and aggregation behaviour of insulin. Irradiation with an average sound intensity of about 180 mW/cm2 leads to a decrease of the unfolding and aggregation temperature up to 7 K.

References

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Paper Citation


in Harvard Style

Pfeiffer H., Chatziathanasiou N., Meersman F., Glorieux C., Heremans K. and Wevers M. (2012). IN-SITU SPECTROSCOPIC INVESTIGATION OF UNFOLDING AND AGGREGATION OF INSULIN UNDER ULTRASONIC EXCITATION - An Ultrasonic Actuator for FTIR-spectrometry on Biomatter . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012) ISBN 978-989-8425-91-1, pages 372-375. DOI: 10.5220/0003797003720375


in Bibtex Style

@conference{biodevices12,
author={Helge Pfeiffer and Nikos Chatziathanasiou and Filip Meersman and Christ Glorieux and Karel Heremans and Martine Wevers},
title={IN-SITU SPECTROSCOPIC INVESTIGATION OF UNFOLDING AND AGGREGATION OF INSULIN UNDER ULTRASONIC EXCITATION - An Ultrasonic Actuator for FTIR-spectrometry on Biomatter},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012)},
year={2012},
pages={372-375},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003797003720375},
isbn={978-989-8425-91-1},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012)
TI - IN-SITU SPECTROSCOPIC INVESTIGATION OF UNFOLDING AND AGGREGATION OF INSULIN UNDER ULTRASONIC EXCITATION - An Ultrasonic Actuator for FTIR-spectrometry on Biomatter
SN - 978-989-8425-91-1
AU - Pfeiffer H.
AU - Chatziathanasiou N.
AU - Meersman F.
AU - Glorieux C.
AU - Heremans K.
AU - Wevers M.
PY - 2012
SP - 372
EP - 375
DO - 10.5220/0003797003720375