Blood Propofol Concentrations: On Demand for Pharmacokinetic/Pharmacodynamics Models and New Measurement Automatic Technologies

S. Campos, A. Silva, P. G. de Pinho, L. Antunes

Abstract

Propofol is a widespread anaesthetic agent in human medicine. It allows the practice of total intravenous anaesthesia through the use of sophisticated delivery systems due to its pharmacokinetic/ pharmacodynamics properties. Three New Zealand White rabbits were anaesthetized with three different infusion rates (70, 100, 130 mg.kg-1.h-1) in a random order, during thirty minutes each. Clinical parameters as well as arterial blood samples were collected at specific time points. Rugloop II Vet software was used to storage all data and to predict the propofol concentrations during the anaesthetic period. A correlation analysis was done between real and predicted propofol concentrations, in each infusion rate. It was only observed a significant correlation between concentrations during the lower infusion rate (70 mg.kg-1.h-1). There is a lack of automatic devices and pharmacokinetic/pharmacodynamics models that allow a real-time or predicted measurement of the propofol concentrations in the patient, for veterinary medicine.

References

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Paper Citation


in Harvard Style

Campos S., Silva A., G. de Pinho P. and Antunes L. (2012). Blood Propofol Concentrations: On Demand for Pharmacokinetic/Pharmacodynamics Models and New Measurement Automatic Technologies . In Proceedings of the International Workshop on Veterinary Biosignals and Biodevices - Volume 1: VBB, (BIOSTEC 2012) ISBN 978-989-8425-94-2, pages 18-23. DOI: 10.5220/0003880900180023


in Bibtex Style

@conference{vbb12,
author={S. Campos and A. Silva and P. G. de Pinho and L. Antunes},
title={Blood Propofol Concentrations: On Demand for Pharmacokinetic/Pharmacodynamics Models and New Measurement Automatic Technologies},
booktitle={Proceedings of the International Workshop on Veterinary Biosignals and Biodevices - Volume 1: VBB, (BIOSTEC 2012)},
year={2012},
pages={18-23},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003880900180023},
isbn={978-989-8425-94-2},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Workshop on Veterinary Biosignals and Biodevices - Volume 1: VBB, (BIOSTEC 2012)
TI - Blood Propofol Concentrations: On Demand for Pharmacokinetic/Pharmacodynamics Models and New Measurement Automatic Technologies
SN - 978-989-8425-94-2
AU - Campos S.
AU - Silva A.
AU - G. de Pinho P.
AU - Antunes L.
PY - 2012
SP - 18
EP - 23
DO - 10.5220/0003880900180023