A BIOMIMETIC AND BIOMECHANICAL APPROACH FOR TISSUE ENGINEERING - Hybrid Nanomaterials and a Piezoelectric Tunable Bending Apparatus for Mechanically Stimulated Osteoblast Cells Growth

Antonio Apicella, Raffella Aversa

Abstract

The research develops and tests new hybrid biomimetic materials that work as mechanically stimulating “scaffolds” to promote early regeneration in implanted bone healing phases. A biomometic nanostructured osteoconductive material coated apparatus is presented. Bioinspired approaches to materials and templated growth of hybrid networks using self-assembled hybrid organic-inorganic interfaces is finalized to extend the use of hybrids in the medical field. Combined in vivo, in vitro and computer-aided simulations have been carried out. Such multidisciplinary approach allowed us to explore many novel ideas in modelling, design and fabrication of new nanostructured biomaterials and scaffolds with enhanced functionality and improved interaction with OB cells. In vivo tests of Titanium screw implanted in rabbit tibiae have shown that mechanical stimulation was induced by the presence of bioactive hybrid perimplantar scaffold resulting in a differentiation and development of mesenchymal tissues. In order to investigate the relationship between bone growth and applied mechanical loading (strain), a piezoelectically driven cantilever and a computer-controlled apparatus for "in vitro" tests has been developed and presented.

References

  1. Montheard JP, Chatzopoulos M, Chappard D. J Macromol Sci Macromol Rev 1992;32:1-34.
  2. Apicella A, et al. Biomaterials 1993;142:83-90.
  3. Schiraldi C, D, Apicella A, Aversa R, De Rosa M (2004) Biomaterials 25 (17):3645-3653.
  4. Aversa R, Apicella D, Apicella A (2009). Dental materials 2009; 25: 678-690
  5. Sorrentino R, Aversa R, Apicella A. Dent Mater 2007; 23: 983-93.
  6. Frost HM. Anat Rec 1990; 226:403-13.
  7. Wolff J. Das Gesetz der Transformation der Knochen. Berlin: A Hirschwald; 1892.
  8. Frost HM. Mathematical elements of lamellar bone remodeling. Springfield: C. C Thomas; 1964. pp. 22-25.
  9. Frost HM. Angle Orthod 1994; 64:175-88.
  10. Apicella A, Hopfenberg Hb. Journal of Applied Polymer Science, 1982; Vol. 27(4), P. 1139-1148, Issn: 0021-8995
  11. Schwartz-Dabney, C.L. (2003) American Journal of Physical Anthropology 120: 252-277.
  12. J Töyräsa, et al., Journal of Biomechanics, Volume 34, Issue 2, 2001, 251-256
  13. J.C. Halpin and J. L. Kardos; Polymer Engineering and Science, 1976, v16, N5, pp 344-352
  14. H. U. COMERON, Clin. Orthop. 208 (1986) 81
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Paper Citation


in Harvard Style

Apicella A. and Aversa R. (2012). A BIOMIMETIC AND BIOMECHANICAL APPROACH FOR TISSUE ENGINEERING - Hybrid Nanomaterials and a Piezoelectric Tunable Bending Apparatus for Mechanically Stimulated Osteoblast Cells Growth . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012) ISBN 978-989-8425-91-1, pages 280-285. DOI: 10.5220/0003887902800285


in Bibtex Style

@conference{biodevices12,
author={Antonio Apicella and Raffella Aversa},
title={A BIOMIMETIC AND BIOMECHANICAL APPROACH FOR TISSUE ENGINEERING - Hybrid Nanomaterials and a Piezoelectric Tunable Bending Apparatus for Mechanically Stimulated Osteoblast Cells Growth},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012)},
year={2012},
pages={280-285},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003887902800285},
isbn={978-989-8425-91-1},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012)
TI - A BIOMIMETIC AND BIOMECHANICAL APPROACH FOR TISSUE ENGINEERING - Hybrid Nanomaterials and a Piezoelectric Tunable Bending Apparatus for Mechanically Stimulated Osteoblast Cells Growth
SN - 978-989-8425-91-1
AU - Apicella A.
AU - Aversa R.
PY - 2012
SP - 280
EP - 285
DO - 10.5220/0003887902800285