Structure Prediction with FAMS for Proteins Screened Critically to Autoimmune Diseases based upon Bioinformatics

Shigeharu Ishida, Hideaki Umeyama, Mitsuo Iwadate, Y-h. Taguchi

Abstract

Drug discovery for autoimmune diseases is recently recognized to be an important task. In this study, we try to perform structure prediction of proteins whose gene promoter regions were previously reported to be specifically methelysed or demethylased commonly for three autoimmune diseases, systemic lupus erythematosus, rheumatoid arthritis, and dermatomyositis. FAMS were employed for this purpose and we can predict three dimensional structure with significantly small enough P-values. Most of them are suggested to be self immunology related proteins and will be important drug target candidates. We also found some proteins which form complex with each other. The possibility of a new drug target, i.e., suppression of protein complex formation is suggested.

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Paper Citation


in Harvard Style

Ishida S., Umeyama H., Iwadate M. and Taguchi Y. (2013). Structure Prediction with FAMS for Proteins Screened Critically to Autoimmune Diseases based upon Bioinformatics . In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013) ISBN 978-989-8565-35-8, pages 261-267. DOI: 10.5220/0004188802610267


in Bibtex Style

@conference{bioinformatics13,
author={Shigeharu Ishida and Hideaki Umeyama and Mitsuo Iwadate and Y-h. Taguchi},
title={Structure Prediction with FAMS for Proteins Screened Critically to Autoimmune Diseases based upon Bioinformatics},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)},
year={2013},
pages={261-267},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004188802610267},
isbn={978-989-8565-35-8},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)
TI - Structure Prediction with FAMS for Proteins Screened Critically to Autoimmune Diseases based upon Bioinformatics
SN - 978-989-8565-35-8
AU - Ishida S.
AU - Umeyama H.
AU - Iwadate M.
AU - Taguchi Y.
PY - 2013
SP - 261
EP - 267
DO - 10.5220/0004188802610267