# Statistical Modeling of Atrioventricular Nodal Function during Atrial Fibrillation - An Update

### Valentina D. A. Corino, Frida Sandberg, Federico Lombardi, Luca T. Mainardi, Leif Sörnmo

#### Abstract

This paper introduces a number of advancements of our recently proposed model of atrioventricular (AV) node function during atrial fibrillation (AF). The model is defined by parameters characterizing the arrival rate of atrial impulses, the probability of an impulse choosing either one of the two AV nodal pathways, the refractory periods of these pathways, and their prolongation. In the updated model, the characterization of AV nodal pathways is made more detailed and the number of pathways is determined by the Bayesian information criterion. The performance is evaluated on ECG data acquired from twenty-five AF patients during rest and head-up tilt test. The results show that the refined AV node model provides significantly better fit than did the original model. During tilt, the AF frequency increased (6:25±0:58 Hz vs. 6:32±0:61 Hz, p < 0:05, rest vs. tilt) and the prolongation of the refractory periods decreased for both pathways (slow pathway: 0:23±0:20 s vs. 0:11±0:10 s, p < 0:001, rest vs. tilt; fast pathway: 0:24±0:31 s vs. 0:16±0:19 s, p < 0:05, rest vs. tilt). These results show that AV node characteristics can be assessed noninvasively for the purpose of quantifying changes induced by autonomic stimulation.

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#### Paper Citation

#### in Harvard Style

D. A. Corino V., Sandberg F., Lombardi F., T. Mainardi L. and Sörnmo L. (2013). **Statistical Modeling of Atrioventricular Nodal Function during Atrial Fibrillation - An Update** . In *Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013)* ISBN 978-989-8565-36-5, pages 25-29. DOI: 10.5220/0004194100250029

#### in Bibtex Style

@conference{biosignals13,

author={Valentina D. A. Corino and Frida Sandberg and Federico Lombardi and Luca T. Mainardi and Leif Sörnmo},

title={Statistical Modeling of Atrioventricular Nodal Function during Atrial Fibrillation - An Update},

booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013)},

year={2013},

pages={25-29},

publisher={SciTePress},

organization={INSTICC},

doi={10.5220/0004194100250029},

isbn={978-989-8565-36-5},

}

#### in EndNote Style

TY - CONF

JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013)

TI - Statistical Modeling of Atrioventricular Nodal Function during Atrial Fibrillation - An Update

SN - 978-989-8565-36-5

AU - D. A. Corino V.

AU - Sandberg F.

AU - Lombardi F.

AU - T. Mainardi L.

AU - Sörnmo L.

PY - 2013

SP - 25

EP - 29

DO - 10.5220/0004194100250029