Radial Basis Function Neural-fuzzy Model for Microarray Signature Identification

Julio De Alejandro Montalvo, George Panoutsos, Mahdi Mahfouf, James W. Catto

Abstract

This paper introduces a Fuzzy entropy-based method for the problem of feature selection. For the first time Fuzzy-Entropy is used to directly link the relative input relevance of a Radial-Basis-Function Neural-Fuzzy modelling structure. This embedded feature selection method uses the model performance as a criterion for the feature selection. The resulting model maintains its simplicity and transparency in the form of a linguistic Fuzzy-Logic rule-base. The proposed methodology is validated using a real biomedical case-study, which concerns the signature selection for the identification of the stage of bladder cancer. The signature selection and predictive modelling results are compared to previous research work on the same dataset, and it is shown that the RBF-NF model outperforms the previous modelling attempts by achieving high predictive accuracy (>90%). The model is shown to maintain its good performance even when using just 10 genes in the gene based signature.

References

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Paper Citation


in Harvard Style

De Alejandro Montalvo J., Panoutsos G., Mahfouf M. and Catto J. (2013). Radial Basis Function Neural-fuzzy Model for Microarray Signature Identification . In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013) ISBN 978-989-8565-35-8, pages 134-139. DOI: 10.5220/0004226801340139


in Bibtex Style

@conference{bioinformatics13,
author={Julio De Alejandro Montalvo and George Panoutsos and Mahdi Mahfouf and James W. Catto},
title={Radial Basis Function Neural-fuzzy Model for Microarray Signature Identification},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)},
year={2013},
pages={134-139},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004226801340139},
isbn={978-989-8565-35-8},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)
TI - Radial Basis Function Neural-fuzzy Model for Microarray Signature Identification
SN - 978-989-8565-35-8
AU - De Alejandro Montalvo J.
AU - Panoutsos G.
AU - Mahfouf M.
AU - Catto J.
PY - 2013
SP - 134
EP - 139
DO - 10.5220/0004226801340139