Quantitative Assessment of Diabetics with Various Degrees of Autonomic Neuropathy

Chuang-Chien Chiu, Shoou-Jeng Yeh, Yi-Chun Kuo

Abstract

In this study, we investigate the feasibility of using power spectral density (PSD) analysis and cross-correlation function (CCF) analysis to assess the healthy subjects and diabetics with mild, moderate and severe autonomic neuropathy. Continuous cerebral blood flow velocity (CBFV) was measured using transcranial Doppler ultrasound (TCD), and continuous arterial blood pressure (ABP) was measured using Finapres device under supine, tilt-up and hyperventilation conditions. In PSD analysis, the results revealed that the autonomic nervous balance to normal subjects declined in trend from supine to hyperventilation in comparison with that of diabetics. The CCF analysis of mean ABP (MABP) and mean CBFV (MCBFV) for each group of patients was calculated in three frequency bands, i.e., very low frequency (VLF), low frequency (LF), and high frequency (HF). The maximum peak value of CCF (Max CCF) and its corresponding standard deviation and time lag were obtained. Max CCF values at LF of normal subjects and patients with diabetes without autonomic neuropathy in both supine and tilt-up positions were significantly larger than that of diabetics with autonomic neuropathy. Max CCF values gradually increased in hyperventilation at VLF from normal subjects to diabetics without autonomic neuropathy, diabetics with mild autonomic neuropathy, and diabetics with severe autonomic neuropathy.

References

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Paper Citation


in Harvard Style

Chiu C., Yeh S. and Kuo Y. (2013). Quantitative Assessment of Diabetics with Various Degrees of Autonomic Neuropathy . In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013) ISBN 978-989-8565-36-5, pages 302-305. DOI: 10.5220/0004230003020305


in Bibtex Style

@conference{biosignals13,
author={Chuang-Chien Chiu and Shoou-Jeng Yeh and Yi-Chun Kuo},
title={Quantitative Assessment of Diabetics with Various Degrees of Autonomic Neuropathy},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013)},
year={2013},
pages={302-305},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004230003020305},
isbn={978-989-8565-36-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013)
TI - Quantitative Assessment of Diabetics with Various Degrees of Autonomic Neuropathy
SN - 978-989-8565-36-5
AU - Chiu C.
AU - Yeh S.
AU - Kuo Y.
PY - 2013
SP - 302
EP - 305
DO - 10.5220/0004230003020305