Algorithm for Testing Behavioural Phenotypes in a Zebrafish Model of Parkinson’s Disease

Angela Pimentel, Hugo Gamboa, Sérgio Reis Cunha, Ana Dulce Correia

Abstract

Parkinson’s disease (PD) is one of the neurodegenerative diseases with an increased prevalence widely studied by the scientific community. Understanding the behaviour related to the disease is an added value for diagnosis and treatment. Thus the use of an animal model for PD that develops similar symptoms to the human being allows to the clinic a larger vision over the health of a patient. Zebrafish can be used to study some human diseases including PD. This work describes the development of an algorithm for the characterization of behaviour in this specie. The biosensor called Marine On-line Biomonitor System (MOBS) is connected electrically to chambers where the specimen of zebrafish moves freely providing a signal that is related with the fish activity. Using the developed algorithm based on signal processing, statistic analysis and machine learning techniques we present classification of a fish as normal or ill and characterize its behaviour.

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Paper Citation


in Harvard Style

Pimentel A., Gamboa H., Reis Cunha S. and Dulce Correia A. (2013). Algorithm for Testing Behavioural Phenotypes in a Zebrafish Model of Parkinson’s Disease . In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013) ISBN 978-989-8565-36-5, pages 196-202. DOI: 10.5220/0004238101960202


in Bibtex Style

@conference{biosignals13,
author={Angela Pimentel and Hugo Gamboa and Sérgio Reis Cunha and Ana Dulce Correia},
title={Algorithm for Testing Behavioural Phenotypes in a Zebrafish Model of Parkinson’s Disease},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013)},
year={2013},
pages={196-202},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004238101960202},
isbn={978-989-8565-36-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013)
TI - Algorithm for Testing Behavioural Phenotypes in a Zebrafish Model of Parkinson’s Disease
SN - 978-989-8565-36-5
AU - Pimentel A.
AU - Gamboa H.
AU - Reis Cunha S.
AU - Dulce Correia A.
PY - 2013
SP - 196
EP - 202
DO - 10.5220/0004238101960202