Improving Neuron Stimulation Efficency by Altering Electrode Geometry

A. Ghazavi, D. Westwick, C. Luk, N. I. Syed, C. Dalton

Abstract

Microelectrode arrays (MEA) are non-invasive tools for recording brain cell activity and have been successfully applied to a variety of neurons. However, MEAs fail where consistent stimulation of neurons is desired over an extended period of time. Here, a model is presented to study features that provide optimum stimulation threshold from different sizes and shapes of electrodes. Both simulation and in vitro experimental results suggest that star-shaped electrodes enable a threshold voltage that is 25% lower than that of an electrode with a circular shape, and are thus considered more efficient for neuronal stimulation. These findings are important as they will help produce more efficient microelectrode arrays for in vivo applications such as prosthetic devices, as well as for long-term in vitro neuron stimulation for studying neuronal networks and function.

References

  1. Buitenweg, J. R., Rutten, W. L. C. and Marani, E., 1999. 'Finite element modeling of the neuron-electrode interface', IEEE Engineering in Medicine and Biology Magazine, vol.19, no.6, pp. 46-52.
  2. Buitenweg, J. R., Rutten, W. L. C., Marani, E., 2003. 'Geometry-based finite-element modeling of the electrical contact between a cultured neuron and a microelectrode', Biomedical Engineering, IEEE Transactions on, vol.50, no.4, pp.501-509.
  3. Choi, C. T. M., You, S., 2012. 'Finite element models of neuron electrode sealing interfaces', Magnetics, IEEE Transactions on, vol.48, no.2, pp.643-646.
  4. Cogan S. F., 2008. 'Neural stimulation and recording electrodes', Ann. Rev. Biomed. Eng, vol.10, pp.275- 309.
  5. Elia S., Lamberti P., Tucci V., 2009. 'A finite element model for the axon of nervous cells', COMSOL Conference.
  6. Huang, X., Nguyen, D., Greve, D. W., Domach, M. M., 2004. 'Simulation of microelectrode impedance changes due to cell growth', Sensors Journal, IEEE, vol.4, no.5, pp. 576- 583.
  7. Lu T. Z., Feng Z-P, 2011. 'A sodium leak current regulates pacemaker activity of adult central pattern generator neurons in Lymnaea Stagnalis'. PLoS ONE, vol.6, no.4, p.e18745.
  8. McCreery, D. B., Agnew, W. F., Yuen, T. G., Bullara, L., 1990. 'Charge density and charge per phase as cofactors in neural injury induced by electrical stimulation'. IEEE Trans. Biomed. Eng., vol.37, no.10, pp.996-1001.
  9. Molleman A., 2003. 'Basic Theoretical Principles, in Patch Clamping: An Introductory Guide To Patch Clamp Electrophysiology', John Wiley & Sons, Ltd, Chichester, UK.ch2.
  10. Moulin C., Gliere A., Barbier D., Joucla S., Yvert B., Mailley P., Guillemaud R., 2008. 'A new 3-D finiteelement model based on thin-film approximation for microelectrode array recording of extracellular action potential' IEEE Trans. Biomed. Eng., Vol.55, pp.683- 92.
  11. Rutten, W. L. C. 2002. Annu. Rev. Biomed. Eng. 4, 407.
  12. Schoen I, Fromherz P., 2007. 'The mechanism of extracellular stimulation of nerve cells on an electrolyte-oxide-semiconductor capacitor'. Biophys. J., 92, vol.92, no.3, pp.1096-1111.
  13. Schoen, I., Fromherz, P., 2008. 'Extracellular stimulation of mammalian neurons through repetitive activation of Na+ channels by weak capacitive currents on a silicon chip'. J Neurophysiol, vol.100, no.1, pp.346-357 Syed, N. I., Zaidi, H., Lovell, P., 1999. U. Windhorst, H. Johansson (Eds.),78 Modern Techniques in Neuroscience Research', Springer, Berlin, Heidelberg , pp. 361-377.
  14. Wei X. F., Grill W. M., 2009. 'Analysis of high-perimeter planar electrodes for efficient neural stimulation'. Front. Neuroeng. , vol.2, no.15.
  15. Yúfera, A., Olmo, Daza, P and Cañete, D. A., 2003. 'Basic
Download


Paper Citation


in Harvard Style

Ghazavi A., Westwick D., Luk C., Syed N. and Dalton C. (2013). Improving Neuron Stimulation Efficency by Altering Electrode Geometry . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2013) ISBN 978-989-8565-34-1, pages 51-56. DOI: 10.5220/0004238900510056


in Bibtex Style

@conference{biodevices13,
author={A. Ghazavi and D. Westwick and C. Luk and N. I. Syed and C. Dalton},
title={Improving Neuron Stimulation Efficency by Altering Electrode Geometry},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2013)},
year={2013},
pages={51-56},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004238900510056},
isbn={978-989-8565-34-1},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2013)
TI - Improving Neuron Stimulation Efficency by Altering Electrode Geometry
SN - 978-989-8565-34-1
AU - Ghazavi A.
AU - Westwick D.
AU - Luk C.
AU - Syed N.
AU - Dalton C.
PY - 2013
SP - 51
EP - 56
DO - 10.5220/0004238900510056