Polymeric Micro Check Valve for Glaucoma Treatment - Considering Rate of Aqueous Humor Formation

Byungphil Mun, Chang-Ju Park, Jaekwon Lee, Jae-Yong An, Seunghwan Moon, Jong-Hyun Lee

Abstract

This paper describes a novel glaucoma drainage device (GDD) to regulate intraocular pressure (IOP) considering the rate of aqueous humor formation. The device functionally consists of a polymeric cannula (silicone tube) and a micro check valve (PDMS: polydimethylsiloxane). The check valve has three layers: a top layer (cover), which has rounded edges to reduce fibrosis, an intermediate layer (thin movable valve membrane), and a bottom layer (base plate). A feedforward channel is employed in the top layer to prevent reverse flow by compensating the pressure of the outlet channel. The thickness of thin the PDMS membrane was determined considering the cracking pressure and the rate of aqueous humor formation. The cracking pressure in-vitro test was conducted at 15 mmHg, which lies within the normal intraocular pressure range (10 ~ 20 mmHg). The experimental mean value and standard deviation of the flow rate at the cracking pressure was 2.18 ± 0.69 µL/min, which is confirmed to cover the rate of aqueous humor formation in the normal human eye (1.5 ~ 3.4 µL/min). Flow in a reverse direction was not observed.

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Paper Citation


in Harvard Style

Lee J., Park C., Mun B., An J., Moon S. and Lee J. (2013). Polymeric Micro Check Valve for Glaucoma Treatment - Considering Rate of Aqueous Humor Formation . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2013) ISBN 978-989-8565-34-1, pages 64-67. DOI: 10.5220/0004244200640067


in Bibtex Style

@conference{biodevices13,
author={Jaekwon Lee and Chang-Ju Park and Byungphil Mun and Jae-Yong An and Seunghwan Moon and Jong-Hyun Lee},
title={Polymeric Micro Check Valve for Glaucoma Treatment - Considering Rate of Aqueous Humor Formation},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2013)},
year={2013},
pages={64-67},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004244200640067},
isbn={978-989-8565-34-1},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2013)
TI - Polymeric Micro Check Valve for Glaucoma Treatment - Considering Rate of Aqueous Humor Formation
SN - 978-989-8565-34-1
AU - Lee J.
AU - Park C.
AU - Mun B.
AU - An J.
AU - Moon S.
AU - Lee J.
PY - 2013
SP - 64
EP - 67
DO - 10.5220/0004244200640067