Comparing Viral (HIV) and Bacterial (Staphylococcus aureus) Infection of the Bone Tissue

Mohammad Ali Moni, Pietro Liò, Luciano Milanesi

Abstract

This paper focuses on the differences between S. aureus bacterial and HIV viral infection of the bone tissue. Both of these infections alters the RANK/RANKL/OPG signalling dynamics that regulates osteoblasts and osteoclasts behavior in bone remodelling. These infections rapidly lead to severe bone loss and it may even spread to other parts of the body. Since both HIV and osteomyelitis cause loss of bone mass, we focused on comparing the dynamics of these diseases by means of computational models. Firstly, we performed meta-analysis on the gene expression data of normal, HIV and osteomyelitis bone conditions and compare the effects of HIV and S. aureus infection. We mainly focused on RANKL/OPG signalling, the TNF and TNF receptor superfamilies and the NF-kB pathway. Using information from the gene expression data, we estimated parameters for a novel model of osteomyelitis. Then we develop another multi strain HIV ODE model incorporating the HAART therapy. Our ODE modelling aims at investigating the dynamics of the effects of osteomyelitis and HIV infection in bone remodelling.

References

  1. Ardura, M., Banchereau, R., Mejias, A., Di Pucchio, T., Glaser, C., Allantaz, F., Pascual, V., Banchereau, J., Chaussabel, D., and Ramilo, O. (2009). Enhanced monocyte response and decreased central memory t cells in children with invasive staphylococcus aureus infections. PLoS One, 4(5):e5446.
  2. Claro, T., Widaa, A., O'Seaghdha, M., Miajlovic, H., Foster, T., O'Brien, F., and Kerrigan, S. (2011). Staphylococcus aureus protein a binds to osteoblasts and triggers signals that weaken bone in osteomyelitis. PloS one, 6(4):e18748.
  3. Cummins, N., Klicpera, A., Sainski, A., Bren, G., Khosla, S., Westendorf, J., and Badley, A. (2011). Human immunodeficiency virus envelope protein gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations. PloS one, 6(9):e24876.
  4. Gentleman, R., Carey, V., Bates, D., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004). Bioconductor: open software development for computational biology and bioinformatics. Genome biology, 5(10):R80.
  5. Gibellini, D., De Crignis, E., Ponti, C., Cimatti, L., Borderi, M., Tschon, M., Giardino, R., and Re, M. (2008). Hiv1 triggers apoptosis in primary osteoblasts and hobit cells through tnfa activation. Journal of medical virology, 80(9):1507-1514.
  6. Joshi-Tope, G., Gillespie, M., Vastrik, I., D'Eustachio, P., Schmidt, E., de Bono, B., Jassal, B., Gopinath, G., Wu, G., Matthews, L., et al. (2005). Reactome: a knowledgebase of biological pathways. Nucleic acids research, 33(suppl 1):D428-D432.
  7. Komarova, S., Smith, R., Dixon, S., Sims, S., and Wahl, L. (2003). Mathematical model predicts a critical role for osteoclast autocrine regulation in the control of bone remodeling. Bone, 33(2):206-215.
  8. Morabito, N. e. a. (2004). Osteoprotegerin and RANKL in the Pathogenesis of Thalassemia-Induced Osteoporosis: New Pieces of the Puzzle. Journal of Bone and Mineral Research, 19(5):722-727.
  9. Parfitt, A. (1994). Osteonal and hemi-osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone. Journal of cellular biochemistry, 55(3):273-286.
  10. Raggatt, L. and Partridge, N. (2010). Cellular and molecular mechanisms of bone remodeling. Journal of Biological Chemistry, 285(33):25103.
  11. Ramilo, O., Allman, W., Chung, W., Mejias, A., Ardura, M., Glaser, C., Wittkowski, K., Piqueras, B., Banchereau, J., Palucka, A., et al. (2007). Gene expression patterns in blood leukocytes discriminate patients with acute infections. Blood, 109(5):2066- 2077.
  12. Reem, A., Manisha, H., Gary, D., Riana, C., Sohrab, D., Nora, G., Natasha, I., Nicole, M., Linda, P., Amy, G., et al. (2011). Osteoimmunopathology in hiv/aids: A translational evidence-based perspective. Pathology research international, 2011.
  13. Sguanci, L., Bagnoli, F., and Lio, P. (2007). Modeling hiv quasispecies evolutionary dynamics. BMC Evolutionary Biology, 7(Suppl 2):S5.
  14. Smoot, M., Ono, K., Ruscheinski, J., Wang, P., and Ideker, T. (2011). Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics, 27(3):431-432.
  15. Soetaert, K., Petzoldt, T., et al. (2010). Inverse modelling, sensitivity and monte carlo analysis in r using package fme. Journal of Statistical Software, 33(3):1-28.
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Paper Citation


in Harvard Style

Ali Moni M., Liò P. and Milanesi L. (2013). Comparing Viral (HIV) and Bacterial (Staphylococcus aureus) Infection of the Bone Tissue . In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013) ISBN 978-989-8565-35-8, pages 196-201. DOI: 10.5220/0004249801960201


in Bibtex Style

@conference{bioinformatics13,
author={Mohammad Ali Moni and Pietro Liò and Luciano Milanesi},
title={Comparing Viral (HIV) and Bacterial (Staphylococcus aureus) Infection of the Bone Tissue},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)},
year={2013},
pages={196-201},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004249801960201},
isbn={978-989-8565-35-8},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)
TI - Comparing Viral (HIV) and Bacterial (Staphylococcus aureus) Infection of the Bone Tissue
SN - 978-989-8565-35-8
AU - Ali Moni M.
AU - Liò P.
AU - Milanesi L.
PY - 2013
SP - 196
EP - 201
DO - 10.5220/0004249801960201