Molding Microchannel and Brain Implant Scaffolds from Microstructured Double Layer Photo Resin Master Casts - Concepts and Examples

Rouhollah Habibey, Asiyeh Golabchi, Axel Blau

Abstract

Replica-casting finds wide application in soft lithography (Qin et al., 2010) and microfluidics (Bettinger et al., 2010). Most commonly, structures are molded with micro- to nano-patterned photoresists as master casts into polydimethylsiloxane (PDMS). PDMS features many favorable properties. It reproduces geometric details with nanometer fidelity, has low cytotoxicity, is transparent in the visible spectrum, biostable both in vitro and in vivo, can be plasma-bonded to itself, has low water permeability and is simple to handle and process. After curing, the PDMS can be easily peeled from the master and the latter usually be reused (Anderson et al., 2000) if patterns are not undercut (Yun et al., 2008). Here, we demonstrate a straightforward replica-molding process that can be exploited for the generation of perforated microchannel scaffolds for the in vitro use in axonal guidance and regeneration studies on microelectrode arrays (MEAs) or the production of tissue-conformal in vivo MEAs for neuroprosthetic applications, respectively.

References

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Paper Citation


in Harvard Style

Habibey R., Golabchi A. and Blau A. (2013). Molding Microchannel and Brain Implant Scaffolds from Microstructured Double Layer Photo Resin Master Casts - Concepts and Examples . In - NEUROTECHNIX, ISBN , pages 0-0


in Bibtex Style

@conference{neurotechnix13,
author={Rouhollah Habibey and Asiyeh Golabchi and Axel Blau},
title={Molding Microchannel and Brain Implant Scaffolds from Microstructured Double Layer Photo Resin Master Casts - Concepts and Examples},
booktitle={ - NEUROTECHNIX,},
year={2013},
pages={},
publisher={SciTePress},
organization={INSTICC},
doi={},
isbn={},
}


in EndNote Style

TY - CONF
JO - - NEUROTECHNIX,
TI - Molding Microchannel and Brain Implant Scaffolds from Microstructured Double Layer Photo Resin Master Casts - Concepts and Examples
SN -
AU - Habibey R.
AU - Golabchi A.
AU - Blau A.
PY - 2013
SP - 0
EP - 0
DO -