Perfusion and Specific Radioprobes for Cardiac Imaging

Filipa Mendes, Lurdes Gano, Célia Fernandes, António Paulo, Isabel Santos

Abstract

Major advancements have been made in treating cardiovascular disease. However, improving diagnosis is crucial, because the detection of the early stages of disease would allow preventative approaches therapy. Myocardial perfusion imaging is in clinical use for decades and is an effective tool for diagnosis, and long-term follow-up of patients with suspected or known coronary artery disease. The technetium-based agents, 99mTc-sestamibi and 99mTc-tetrofosmin, are widely used myocardial blood flow tracers. However, since both present drawbacks in their biodistribution properties, there is now resurgence in the study of both neutral and cationic technetium agents to further improve the characteristics of perfusion radiopharmaceuticals. Despite all the success of perfusion imaging, a unique strength of nuclear imaging is its ability to provide tools for imaging processes at molecular and cellular levels in intact organisms under a wide variety of physiologic conditions. Advances in new specific imaging agents that identify myocardium injury and cellular dysfunction may contribute to the improvement of diagnosis and eventually better therapeutic approaches. In this communication, we will review perfusion agents and their biological mechanism of uptake. We will also discuss examples of target-specific radiopharmaceuticals for cardiac imaging, including advances in pre-clinical imaging approaches.

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Paper Citation


in Harvard Style

Mendes F., Gano L., Fernandes C., Paulo A. and Santos I. (2013). Perfusion and Specific Radioprobes for Cardiac Imaging . In Proceedings of the International Congress on Cardiovascular Technologies - Volume 1: VisualCardio, (CARDIOTECHNIX 2013) ISBN 978-989-8565-78-5, pages 79-83. DOI: 10.5220/0004664300790083


in Bibtex Style

@conference{visualcardio13,
author={Filipa Mendes and Lurdes Gano and Célia Fernandes and António Paulo and Isabel Santos},
title={Perfusion and Specific Radioprobes for Cardiac Imaging},
booktitle={Proceedings of the International Congress on Cardiovascular Technologies - Volume 1: VisualCardio, (CARDIOTECHNIX 2013)},
year={2013},
pages={79-83},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004664300790083},
isbn={978-989-8565-78-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Congress on Cardiovascular Technologies - Volume 1: VisualCardio, (CARDIOTECHNIX 2013)
TI - Perfusion and Specific Radioprobes for Cardiac Imaging
SN - 978-989-8565-78-5
AU - Mendes F.
AU - Gano L.
AU - Fernandes C.
AU - Paulo A.
AU - Santos I.
PY - 2013
SP - 79
EP - 83
DO - 10.5220/0004664300790083