Neuromuscular Electrical Stimulation and Biofeedback Therapy to Improve Endometrial Growth in Patients with Thin Endometrium - A Randomized Controlled Study

Madafeitom Meheza Abide Bodombossou Djobo, Xiaoli Chen, Zhuangyu He, Xiaomiao Zhao, Shaoqing Chen, Qingxue Zhang, Dongzi Yang

Abstract

Objective: to evaluate the efficacy of noninvasive Neuromuscular electrical stimulation (NMES) in the management of thin endometrium patients. Design: A randomized control study Patients: 115 patients with thin endometrium (≤7mm) and history of infertility Interventions: NMES group received NMES 3 to 4 times during one menstruation cycle from day 9-10 and in comparison, a similar group of subjects received the aspirin treatment protocol. Outcomes: Pre and post-treatment endometrium thickness, endometrial volume and Power Doppler Angiography (PDA) related parameters measured by three-dimensional ultrasound. Results: the endometrium was thicker in the NMES group compared with that in aspirin group [8.00 versus 7.72; P=0.028]. 32/55(58%) developed endometrial thickness equal to or more than 8 mm after NMES therapy in the NMES group and 16/48(33%) in aspirin group. The endometrial and sub-endometrial volumes at final point also differ significantly between groups [2.58 versus 2.28; P=0.008 and 1.40 versus 1.21; P=0.001 for endometrial volume and sub-endometrial volume respectively. The two groups did not differ significantly regarding endometrial vascularization index (VI) and vascularization flow index (VFI) at final point. But in another hand, endometrial flow index (FI), sub-endometrial vascularization index (sub-VI), sub-endometrial flow index (sub-FI) and sub-endometrial vascularization flow index (sub-VFI) differed statistically between groups (P=0.032, P=0.022, P=0.006 and P=0.018 respectively). Conclusion: NMES group showed better endometrial thickness, volume and vascularization than aspirin group. NMES may have a proliferative effect on endometrium and improve its vascularization.

References

  1. Khairy, M. et al., 2007. Aspirin in women undergoing in vitro fertilization treatment: a systematic review and meta-analysis. Fertil Steril, 2007. 88(4): p. 822-31.
  2. Sher, G. and J. D. Fisch., 2002. Effect of vaginal sildenafil on the outcome of in vitro fertilization (IVF) after multiple IVF failures attributed to poor endometrial development. Fertil Steril, 2002. 78(5): p. 1073-6.
  3. Bodombossou-Djobo, M. M. et al., 2011. Neuromuscular electrical stimulation and biofeedback therapy may improve endometrial growth for patients with thin endometrium during frozen-thawed embryo transfer: a preliminary report. Reprod Biol Endocrinol. 9: p. 122.
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in Harvard Style

Meheza Abide Bodombossou Djobo M., Chen X., He Z., Zhao X., Chen S., Zhang Q. and Yang D. (2013). Neuromuscular Electrical Stimulation and Biofeedback Therapy to Improve Endometrial Growth in Patients with Thin Endometrium - A Randomized Controlled Study . In - NEUROTECHNIX, ISBN , pages 0-0


in Bibtex Style

@conference{neurotechnix13,
author={Madafeitom Meheza Abide Bodombossou Djobo and Xiaoli Chen and Zhuangyu He and Xiaomiao Zhao and Shaoqing Chen and Qingxue Zhang and Dongzi Yang},
title={Neuromuscular Electrical Stimulation and Biofeedback Therapy to Improve Endometrial Growth in Patients with Thin Endometrium - A Randomized Controlled Study},
booktitle={ - NEUROTECHNIX,},
year={2013},
pages={},
publisher={SciTePress},
organization={INSTICC},
doi={},
isbn={},
}


in EndNote Style

TY - CONF
JO - - NEUROTECHNIX,
TI - Neuromuscular Electrical Stimulation and Biofeedback Therapy to Improve Endometrial Growth in Patients with Thin Endometrium - A Randomized Controlled Study
SN -
AU - Meheza Abide Bodombossou Djobo M.
AU - Chen X.
AU - He Z.
AU - Zhao X.
AU - Chen S.
AU - Zhang Q.
AU - Yang D.
PY - 2013
SP - 0
EP - 0
DO -