Evaluation of the Effects of Dose on Lung Ventilation Calculated from 4D-CT using Deformable Image Registration - An Application of a Ventilation Calculation Algorithm based on 4D-CT

Kujtim Latifi, Thomas J. Dilling, Craig W. Stevens, Vladimir Feygelman, Eduardo G. Moros, Geoffrey G. Zhang

Abstract

Ventilation derived from 4D-CT using deformable image registration (DIR) has been found correlate to the result from a conventional modality very well. How radiation affects ventilation in lungs is still not clearly studied. In this paper, ventilation versus radiation dose is investigated using ΔV method, a ventilation calculation algorithm based on 4D-CT and DIR. Diffeomorphic morphons was used as the DIR tool. Tidal volume normalized ventilation was used in this study. A total of 20 SBRT lung cancer patients’ 4D-CT and planning dose data were retrospectively analysed. All the patients had two sets of 4D-CT, one at pre-treatment and one post treatment. Ventilation distributions were calculated based on the two sets of 4D-CT for each case. The two ventilation data sets were aligned using DIR. Radiation dose distributions were resampled to match the resolution of CT images. A ventilation (or ventilation change) and dose values were thus associated to each voxel of the CT images. A function (ventilation change) – dose – volume surface was generated for each case. Average ventilation was found degraded in higher than 20 Gy dose regions for 16 out of the 20 cases. This result can be applied in treatment planning to spare functional lung volumes.

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Paper Citation


in Harvard Style

Latifi K., J. Dilling T., W. Stevens C., Feygelman V., G. Moros E. and G. Zhang G. (2014). Evaluation of the Effects of Dose on Lung Ventilation Calculated from 4D-CT using Deformable Image Registration - An Application of a Ventilation Calculation Algorithm based on 4D-CT . In Proceedings of the International Conference on Bioimaging - Volume 1: BIOIMAGING, (BIOSTEC 2014) ISBN 978-989-758-014-7, pages 5-11. DOI: 10.5220/0004719700050011


in Bibtex Style

@conference{bioimaging14,
author={Kujtim Latifi and Thomas J. Dilling and Craig W. Stevens and Vladimir Feygelman and Eduardo G. Moros and Geoffrey G. Zhang},
title={Evaluation of the Effects of Dose on Lung Ventilation Calculated from 4D-CT using Deformable Image Registration - An Application of a Ventilation Calculation Algorithm based on 4D-CT},
booktitle={Proceedings of the International Conference on Bioimaging - Volume 1: BIOIMAGING, (BIOSTEC 2014)},
year={2014},
pages={5-11},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004719700050011},
isbn={978-989-758-014-7},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bioimaging - Volume 1: BIOIMAGING, (BIOSTEC 2014)
TI - Evaluation of the Effects of Dose on Lung Ventilation Calculated from 4D-CT using Deformable Image Registration - An Application of a Ventilation Calculation Algorithm based on 4D-CT
SN - 978-989-758-014-7
AU - Latifi K.
AU - J. Dilling T.
AU - W. Stevens C.
AU - Feygelman V.
AU - G. Moros E.
AU - G. Zhang G.
PY - 2014
SP - 5
EP - 11
DO - 10.5220/0004719700050011