Estimation of Arterial Stiffness through Pulse Transit Time Measurement

Avinash S. Vaidya, T. S. L. Radhika, M. B. Srinivas, Mannan Mridha

Abstract

Early detection of cardiovascular disease (CVD) and its treatment is significantly expected to reduce the mortality rate across the world. While several diagnostic techniques have been developed for early detection of the CVD, recent focus has been on measuring the ‘arterial stiffness’, which appears to be a major indicator of onset of cardio vascular disease. In this work, authors consider three mathematical models that relate pulse wave velocity (PWV) with arterial stiffness. While one model considers blood to be a non-viscous and incompressible fluid, the other considers it to be a viscous and compressible. Pulse transit time has been measured experimentally for five different individuals of different ages and heights from where PWV has been estimated. Using values of PWV, Young’s modulus of elasticity has been derived. Data related to arteries such as radius, wall thickness, density and viscosity of blood have been taken from published literature where these parameters have been measured using techniques such as MRI. Initial results indicate that different models predict different estimates for arterial stiffness that depend on assumptions made.

References

  1. Fung, P., Dumont, G., Ries, C., Mott, C., and Ansermino, M., 2004. Continuous Noninvasive Blood Pressure Measurement by Pulse Transit Time, in Proceedings of the 26th Annual International Conference of the IEEE EMBS, San Francisco, CA, USA.
  2. Avril, S., Huntley, J. M., and Cusack, R., 2008. Charachterization of Wall Stiffness in A Blood Vessel Using Cine-PC-MRI, in XI International Congress and Exposition, Orlando, Florida, USA.
  3. Hasegawa, H., and Kanai, H., 2004. Measurement of Elastic Moduli of the Arterial Wall at Multiple Frequencies by Remote Actuation for Assessment of Viscoelasticity, Japanese Journal of Applied Physics, vol. Vol. 43, no. No. 5B, p. 3197-3203.
  4. Mazumdar, J.N., 2004. Bio-Fluid Mechanics, World Scientific Publishing. Singapore.
  5. Ku2, Y. M., Kim1, Y. O., Kim3, J. I., Choi4, Y. J., Yoon1, S. A. and Kim1, Y. S., 2006. Ultrasonographic measurement of intima-media thickness of radial artery in pre-dialysis uraemic patients: comparison with histological examination, Nephrol Dial Transplant, vol. 21, pp. 715-720,
  6. Kurtz, M., 2003. Standard Handbook of Biomedical Engineering and Design, McGraw-Hill Professional Publishing
  7. Olufsen, M. S., Peskin, C. S., Kim, W. Y., Pedersen, E. M., Nadim, A. and Larsen, J., 2000. Numerical Simulation and Experimental Validation of Blood Flow in Arteries with Structured-Tree Outflow Conditions, Annals of Biomedical Engineering, vol. 28, pp. 1281-1299.
  8. Fung, Y. C., 1984. Biodynamics Circulation, Springer Verlag, New York:
  9. Ye, S. Y., Kim, G. R., Jung, D. K., Baik, S. W. and Jeon, G. R., 2010. Estimation of Systolic and Diastolic Pressure using the Pulse Transit Time," World Academy of Science, Engineering and Technology, pp. 726-731.
  10. Nadeem, S., Noreen Sher Akbar, Awatif A. Hendi, Tasawar Hayat, 2011. Power law fluid model for blood flow through a tapered artery with a stenosis, Applied Mathematics and Computation, pp. 7108- 7116.
  11. Basu Mallik, B., Saktipada Nanda, Bhabatosh Das, Debanshu Saha, Debanu Shankar Das and Koustav Paul. 2013. A Non Newtonian fluid model for blood flow using PowerLaw through an Artherosclerotic arterial segment having Slip velocity. IJPCBS, pp. 752-760.
Download


Paper Citation


in Harvard Style

S. Vaidya A., S. L. Radhika T., B. Srinivas M. and Mridha M. (2014). Estimation of Arterial Stiffness through Pulse Transit Time Measurement . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2014) ISBN 978-989-758-013-0, pages 238-242. DOI: 10.5220/0004912002380242


in Bibtex Style

@conference{biodevices14,
author={Avinash S. Vaidya and T. S. L. Radhika and M. B. Srinivas and Mannan Mridha},
title={Estimation of Arterial Stiffness through Pulse Transit Time Measurement},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2014)},
year={2014},
pages={238-242},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004912002380242},
isbn={978-989-758-013-0},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2014)
TI - Estimation of Arterial Stiffness through Pulse Transit Time Measurement
SN - 978-989-758-013-0
AU - S. Vaidya A.
AU - S. L. Radhika T.
AU - B. Srinivas M.
AU - Mridha M.
PY - 2014
SP - 238
EP - 242
DO - 10.5220/0004912002380242