The Homologous Recombination Mathematical Model and the Role of miRNAs in ATM/ATR-dependent and BRCA1/BRCA2-dependent DSBs Repair Pathway - Outline of the Project

Katarzyna Jonak, Monika Kurpas, Krzysztof Puszyński

Abstract

DNA double strand breaks (DSBs) are known to be one of the most cytotoxic lesions, caused by exposure to ionizing radiation or clastogenic drugs. Maintaining the genomic integrity through DNA repair processes is essential for proper functioning of the organisms. Therefore, it is important to study interactions between different components of DSBs detection modules and repair systems and to model cellular response to the signals from the specific elements of these pathways. Homologous recombination (HR) is one of the repair pathways in eukaryotic cells and is limited to late S phase and G2 phase of cell cycle. We propose a mathematical model that focuses on the interactions between different components of HR. The model includes the effects of the DNA damages on ATM and ATR detection modules and the activation of key proteins involved in HR, such as BRCA1, BRCA2 and Rad51. It describes the connections between HR and checkpoints proteins, as well as the effect of known specific miRNAs responsible for regulation of transcription of the proteins involved in HR pathway. The purpose of the project is to illustrate the processes occurring during DNA repair. The project will allow to understand the interactions between molecules, probably investigate new components of the HR network, and contribute to putting the hypotheses on possible treatment of different diseases at the level of the cellular pathways.

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Paper Citation


in Harvard Style

Jonak K., Kurpas M. and Puszyński K. (2014). The Homologous Recombination Mathematical Model and the Role of miRNAs in ATM/ATR-dependent and BRCA1/BRCA2-dependent DSBs Repair Pathway - Outline of the Project . In Doctoral Consortium - DCBIOSTEC, (BIOSTEC 2014) ISBN Not Available, pages 41-46


in Bibtex Style

@conference{dcbiostec14,
author={Katarzyna Jonak and Monika Kurpas and Krzysztof Puszyński},
title={The Homologous Recombination Mathematical Model and the Role of miRNAs in ATM/ATR-dependent and BRCA1/BRCA2-dependent DSBs Repair Pathway - Outline of the Project},
booktitle={Doctoral Consortium - DCBIOSTEC, (BIOSTEC 2014)},
year={2014},
pages={41-46},
publisher={SciTePress},
organization={INSTICC},
doi={},
isbn={Not Available},
}


in EndNote Style

TY - CONF
JO - Doctoral Consortium - DCBIOSTEC, (BIOSTEC 2014)
TI - The Homologous Recombination Mathematical Model and the Role of miRNAs in ATM/ATR-dependent and BRCA1/BRCA2-dependent DSBs Repair Pathway - Outline of the Project
SN - Not Available
AU - Jonak K.
AU - Kurpas M.
AU - Puszyński K.
PY - 2014
SP - 41
EP - 46
DO -