Analysis of Glioblastoma’s Peritumoral Brain Zone - Developing of Per-operative Analysis and New Therapeutic Targets

Jean-Michel Lemée, Anne Clavreul, Philippe Menei

Abstract

GB is the most frequent and aggressive primary tumor of the central nervous system. The mechanisms of recurrence remain unclear but the infiltration of the peritumoral brain zone by GB cells may be considered as the explanation of the high rate of local recurrences. A better understanding of the characteristics of the PBZ is critical to understand the mechanisms of GB recurrence, optimize the quality of the surgical resection and develop new therapies. During the first part of my PhD, we studied the heterogeneity of the glioblastoma’s peritumoral brain zone (GB-PBZ) using the different techniques used routinely to analyze tumor samples, identifying several alterations specific to the GB-PBZ. Also, we solved a methodological problem with the definition of the best control for brain tumor proteomic analysis. The second part of my PhD will be focused on the development of per-operative analysis of the GB-PBZ to guide the surgical resection of the tumor, and the molecular analysis of the GB-PBZ to develop new therapeutic targets for GB treatment. First, we decided to study two modern techniques of microscopy: the Second Harmonic Imaging Microscopy and the Two Photons-Excited Fluorescence to allow a fast and reproducible per-operative analysis of the GB-PBZ with the aim to optimize the complete resection of the tumor. After the validation of the proteins found in the multimodal analysis of the GB-PBZ, we will assess the expression of these proteins in a cohort of patients from the national clinico-biological collection of GB to assess if these biomarkers can be used as therapeutic targets or as target for vectorized nanotherapies.

References

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Paper Citation


in Harvard Style

Lemée J., Clavreul A. and Menei P. (2014). Analysis of Glioblastoma’s Peritumoral Brain Zone - Developing of Per-operative Analysis and New Therapeutic Targets . In Doctoral Consortium - DCBIOSTEC, (BIOSTEC 2014) ISBN Not Available, pages 54-59


in Bibtex Style

@conference{dcbiostec14,
author={Jean-Michel Lemée and Anne Clavreul and Philippe Menei},
title={Analysis of Glioblastoma’s Peritumoral Brain Zone - Developing of Per-operative Analysis and New Therapeutic Targets},
booktitle={Doctoral Consortium - DCBIOSTEC, (BIOSTEC 2014)},
year={2014},
pages={54-59},
publisher={SciTePress},
organization={INSTICC},
doi={},
isbn={Not Available},
}


in EndNote Style

TY - CONF
JO - Doctoral Consortium - DCBIOSTEC, (BIOSTEC 2014)
TI - Analysis of Glioblastoma’s Peritumoral Brain Zone - Developing of Per-operative Analysis and New Therapeutic Targets
SN - Not Available
AU - Lemée J.
AU - Clavreul A.
AU - Menei P.
PY - 2014
SP - 54
EP - 59
DO -