DNA Damage Detection and its Impact on the Cell Cycle

Monika Kurpas, Katarzyna Jonak, Krzysztof Puszyński

Abstract

During evolution number of mechanisms that protect cells from damages evolved to prevent their death and lesions transformation to future generations. For efficient repair it is necessary to detect damages quickly and then transfer the signal to other components of cells. This process takes place in a manner specific to the type of lesion. ATR (ataxia telangiectasia mutated and Rad3-related) module is activated by the presence of DNA single stranded breaks (SSBs) in cell, which are caused by resection of various types of lesions or by stalled replication forks. Double strand breaks (DSBs) are detected indirectly by ataxia telangiectasia mutated (ATM). These proteins are involved in the activation of the signaling cascade, as a result of which tumor suppressor p53 is activated and decision about future fate of cells is taken. If the damage is too extensive cell undergoes apoptosis. If damage is repairable, the cell cycle is arrested and damage repair occurs. Current status of DNA is controlled in cell cycle checkpoints. Cell cycle arrest requires signal from the ATM or ATR and Chk1 and Chk2 (checkpoint kinases). At this point, we have created mathematical models of ATR-p53 and ATM-p53 signaling pathways. We plan to combine the developed DNA damage detection pathways and connect them with the cell cycle. Our purpose is to examine the impact of ATM-ATR-p53 path on the cell cycle and examine influence of cell cycle on this path. We also plan to investigate how disabling of selected interactions between molecules may influence the DNA damage response system.

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Paper Citation


in Harvard Style

Kurpas M., Jonak K. and Puszyński K. (2014). DNA Damage Detection and its Impact on the Cell Cycle . In Doctoral Consortium - DCBIOSTEC, (BIOSTEC 2014) ISBN Not Available, pages 67-73


in Bibtex Style

@conference{dcbiostec14,
author={Monika Kurpas and Katarzyna Jonak and Krzysztof Puszyński},
title={DNA Damage Detection and its Impact on the Cell Cycle},
booktitle={Doctoral Consortium - DCBIOSTEC, (BIOSTEC 2014)},
year={2014},
pages={67-73},
publisher={SciTePress},
organization={INSTICC},
doi={},
isbn={Not Available},
}


in EndNote Style

TY - CONF
JO - Doctoral Consortium - DCBIOSTEC, (BIOSTEC 2014)
TI - DNA Damage Detection and its Impact on the Cell Cycle
SN - Not Available
AU - Kurpas M.
AU - Jonak K.
AU - Puszyński K.
PY - 2014
SP - 67
EP - 73
DO -