Design of a Myelin Basic Protein Biosensor based on EnFET Technology

Jorge Guerrero, Roberto Ambrosio, Amanda Carrillo

Abstract

In this work, the design of a biosensor based on FET technology have been proposed, simulating the modification to the gate of an Ion Sensitive Field-Effect Transistor (ISFET) with a synthetic polymer to entrap the desired analyte which contains Myelin Basic Protein (MBP). This analyte is generally used in test to find out if someone is suffering a demyelinating disease, and is commonly detected by Enzyme Linked Immunosorbent Assays (ELISA). Based on this principle, we propose a simpler method, fundamented on Enzyme Field-Effect Transistor (EnFET) technology in order to develop a new device applied to the diagnosis of demyelinating diseases. Simulation examples are used in order to demonstrate the functionality for this type of biosensor to its exposure to MBP at concentrations of 10-4 to 10-1 mol/L, where the amount of analyte in the receptor located at the top of the gate will determine the level of voltage applied to create a channel and activate the device.

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Paper Citation


in Harvard Style

Guerrero J., Ambrosio R. and Carrillo A. (2015). Design of a Myelin Basic Protein Biosensor based on EnFET Technology . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015) ISBN 978-989-758-071-0, pages 78-82. DOI: 10.5220/0005180700780082


in Bibtex Style

@conference{biodevices15,
author={Jorge Guerrero and Roberto Ambrosio and Amanda Carrillo},
title={Design of a Myelin Basic Protein Biosensor based on EnFET Technology},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015)},
year={2015},
pages={78-82},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005180700780082},
isbn={978-989-758-071-0},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015)
TI - Design of a Myelin Basic Protein Biosensor based on EnFET Technology
SN - 978-989-758-071-0
AU - Guerrero J.
AU - Ambrosio R.
AU - Carrillo A.
PY - 2015
SP - 78
EP - 82
DO - 10.5220/0005180700780082